Therapeutic approach using analysis of type III IFN SNPs in upper respiratory disease

使用 III 型 IFN SNP 分析治疗上呼吸道疾病的方法

• 批准号: 24659750
• 负责人: HIMI Tetsuo
• 金额: $ 2.41万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659750/
• 关键词: インターフェロン; 遺伝子多型; 鼻粘膜; 上皮細胞; ウイルス受容体; ＲＳＶ; 自然免疫; プロテアーゼ; クルクミン; タイト結合; RSウイルス; ウイルス複製

Respiratory syncytial virus (RSV) is the major cause of respiratory disease. The human nasal epithelium is the first line of defense during respiratory virus infection. RSV could infect these cells from apical but not basolateral side, and enhanced the expression of tight junction proteins. RSV infection induces polarity in the infected cells, thereby spreading the infection.As an innate immune response against diverse viral infections, a host induces two types of IFN, type-I and type-III. Type -III, but not type-I, contributes to the main first line defense against respiratory virus infection in nasal mucosa. Curcumin and Humulon can prevent the replication of RSV and the epithelial responses to it. Moreover, Clarithromycin also suppressed RSV-induced PAF receptor expression and adhesion of fluorescein-labeled S. pneumoniae cells to A549 cells. These are useful biological products for the prevention and therapy for RSV infection.

呼吸道合胞病毒（RSV）是呼吸道疾病的主要病原。人鼻粘膜上皮是呼吸道病毒感染的第一道防线。RSV可从顶侧而非基底侧感染这些细胞，并增强了紧密连接蛋白的表达。RSV感染诱导受感染细胞的极性，从而传播感染。作为针对不同病毒感染的先天免疫应答，宿主诱导两种类型的IFN，I型和III型。III型，而不是I型，有助于鼻粘膜中抵抗呼吸道病毒感染的主要第一线防御。姜黄素和Humulon能抑制RSV的复制和上皮细胞对RSV的反应，克拉霉素还能抑制RSV诱导的PAF受体表达和荧光素标记的S. pneumoniae细胞对A549细胞的增殖。这些是用于预防和治疗RSV感染的有用生物制品。

项目成果

宿題報告上気道炎症における鼻粘膜の役割

作业报告 鼻粘膜在上呼吸道炎症中的作用

• 发表时间: 2012
• 作者: Yamamoto M;Tabeya T;Naishiro Y;Yajima H;Ishigami K;Shimizu Y;Obara M;Suzuki C;Yamashita K;Yamamot H;Hayashi T;Sasaki S;Suzuki Y;Nishimoto N;Honda S;Takahashi H;Imai K;Shinomura Y;氷見徹夫;氷見徹夫;氷見徹夫
• 通讯作者: 氷見徹夫

Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases

• DOI: 10.1007/s10165-011-0532-6
• 发表时间: 2012-06-01
• 期刊: MODERN RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Yamamoto, Motohisa;Tabeya, Tetsuya;Shinomura, Yasuhisa
• 通讯作者: Shinomura, Yasuhisa

鼻粘膜上皮におけるＲＳウイルス感染メカニズムと新たな予防戦略

鼻粘膜上皮呼吸道合胞病毒感染机制及预防新策略

• 作者: Yamamoto M;Tabeya T;Naishiro Y;Yajima H;Ishigami K;Shimizu Y;Obara M;Suzuki C;Yamashita K;Yamamot H;Hayashi T;Sasaki S;Suzuki Y;Nishimoto N;Honda S;Takahashi H;Imai K;Shinomura Y;氷見徹夫;氷見徹夫;氷見徹夫;氷見徹夫;Shirasaki H;氷見徹夫;高野賢一;高野賢一，氷見徹夫
• 通讯作者: 高野賢一，氷見徹夫

Localization and upregulation of CysLT2 R in perennial allergic rhinitis

CysLT2 R 在常年性过敏性鼻炎中的定位和上调

• 发表时间: 2012
• 作者: Yamamoto M;Tabeya T;Naishiro Y;Yajima H;Ishigami K;Shimizu Y;Obara M;Suzuki C;Yamashita K;Yamamot H;Hayashi T;Sasaki S;Suzuki Y;Nishimoto N;Honda S;Takahashi H;Imai K;Shinomura Y;氷見徹夫;氷見徹夫;氷見徹夫;氷見徹夫;Shirasaki H
• 通讯作者: Shirasaki H

鼻粘膜上皮と樹状細胞の役割

鼻粘膜上皮和树突状细胞的作用

• 作者: Yamamoto M;Tabeya T;Naishiro Y;Yajima H;Ishigami K;Shimizu Y;Obara M;Suzuki C;Yamashita K;Yamamot H;Hayashi T;Sasaki S;Suzuki Y;Nishimoto N;Honda S;Takahashi H;Imai K;Shinomura Y;氷見徹夫;氷見徹夫;氷見徹夫;氷見徹夫;Shirasaki H;氷見徹夫;高野賢一
• 通讯作者: 高野賢一