Anatomical and physiological characteristics of the peripheral vestibular endorgan, vestibular nucleus and vestibulo-cerebellum

外周前庭内器、前庭核和前庭小脑的解剖和生理特征

• 批准号: 03670815
• 负责人: HIMI Tetsuo
• 金额: $ 1.22万
• 依托单位: Sapporo Medical University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670815/
• 关键词: Vestibular endorgan; Vestibular nucleus; Vertical eye movement; Brain stem; Substance P; NK1 receptor; RT-PCR; 眼球運動; 前庭小脳; 内耳; 前庭神経; 細胞接着因子; 発生学; 免疫組織

1. In vestibular system, little is known of the functional significance of Substance P (SP). In this study, the expression of mRNA encoding Neurokinin 1 receptor (NK1R) as a receptor of SP was examined in rat inner ear using RT-PCR method. NK1R mRNA was observed in both cochlear tissue and vestibular one.2. Spontaneous nystagmus was examined in patients with lateral medullary infarct syndrome. It is suspected that torsional eye movements in this syndrome may originate not in ventral but in rostral and dorsal lesions of the medulla, including the vestibular nucleus, which is related to torsional and vertical eye movements.3. The new etiology of the downbeat nystagmus was clarified. The presented case shows clear evidence of downbeat nystagmus arising from compression of vertebral arteries to the medulla oblongata. Surgical neurovascular decompression reveres the progression of symptoms.4. The phenomenon appeared to be part of the "vestibular agnosia" did not cause by a lesion of the vestibular nucleus and/or vestibular endorgans.

1. P物质（Substance P，SP）在前庭系统中的功能意义尚不清楚。本研究应用RT-PCR方法检测了SP受体神经激肽1受体（NK 1 R）mRNA在大鼠内耳的表达。NK 1 R mRNA在耳蜗和前庭组织中均有表达.自发性眼球震颤是在延髓外侧梗死综合征患者中进行检查的。本综合征的眼球扭转运动可能不是起源于延髓腹侧，而是起源于延髓头端和背侧的病变，包括前庭核，与眼球的扭转和垂直运动有关.阐明了下搏性眼球震颤的新病因。所提出的情况下，显示了明确的证据，下拍眼球震颤所产生的压缩椎动脉延髓。手术神经血管减压可逆转脑血管病的进展.这种现象似乎是“前庭失认症”的一部分，而不是由前庭核和/或前庭终器的病变引起的。

项目成果

Tetsuo Himi, Akikatsu Kataura: "Oblique periodic alternating nystagmus provoked by intermittent vertebral artery compression" Equilibrium Res. 52. 524-529 (1993)

Tetsuo Himi、Akikatsu Kataura：“间歇性椎动脉受压引起的斜周期性交替眼球震颤”平衡研究。

Tetsuo Himi, Hideaki Shirasaki, Iwao Yoshioka, Akikatsu Kataura: "Neurokinin 1 receptor mRNA detected by RT-PCR in rat inner ear" Hearing Res. (in submitted).

Tetsuo Himi、Hideaki Shirasaki、Iwao Yoshioka、Akikatsu Kataura：“通过 RT-PCR 检测大鼠内耳中的神经激肽 1 受体 mRNA”听力研究。

氷見徹夫: "神経血管圧迫症候群" 日耳鼻. 96. 720-723 (1993)

Tetsuo Himi：“神经血管压迫综合症”Nippon Otohana 96. 720-723 (1993)

氷見徹夫: "第VIII脳神経の神経血管圧迫症候群" 日耳鼻. 96. 720-723 (1993)

Tetsuo Himi：“第八脑神经的神经血管压迫综合症”Nippon Otori-nose 96. 720-723 (1993)。

Tetsuo Himi: "Downbeat Nystagmus with compression of Medulla oblongata by the Dolichooctatic Vertebral Arteries" Am J Otol. 16(in press). (1995)

Tetsuo Himi：“多利丘克椎动脉压迫延髓而导致眼球震颤”Am J Otol。