Analysis of relationship in immune barrier function between human nasal epithelial cell and dendritic cell.

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Analysis of a immune barrier function with primary culture system of human nasal mucosa epithelium is important to establish a methodology of inflammation control by trans-nasal administration. Tight junction is one of an important factor contributing to permeability of a material, and it is important to study a factor regulating this function. Furthermore, examination of immunocompetent cell about an antigen sampling such as dendritic cell contributes to establish the mechanism of immune therapy for allergic rhinitis or upper respiratory infection by trans-nasal administration.