Molecular dissection of periodontal susceptibility for generation of predictive dentistry

为了评估宿主对牙周炎的易感性，我们分析了牙周细胞内针对细胞间病原体的杀菌分子基础，在进入牙龈上皮细胞后，牙龈假单胞菌被分选到早期的内体，细胞内一半的病原体通过SNARE蛋白VAMP2运输到循环途径，使细菌能够退出细胞外环境。而剩下的一半则被归类为自噬。这是一个非常独特的发现，表明两个不同的细胞器共同作用形成另一个细胞器。

We analyzed microbicidal molecular basis against intercellular pathogens in periodontal cells in order to evaluate host susceptibility to periodontitis for future predictive dentistry.Following the entry to gingival epithelial cells, P. gingivalis is sorted to early endosomes, and the half of the intracellular pathogens are transported to recycling pathway via SNARE protein, VAMP2, which allows the bacterial exit to the extracellular circumstances. While, remaining half are sorted to autophagosome. The machinery is found to be formed in contact sites between endoplasmic reticulum and mitochondria, which is a very unique finding indicating that 2 different organelle make a concerted effort to the formation of another organelle.