Mechanism of transcriptional regulation from arachnoid cells to endothelial cells

蛛网膜细胞在蛛网膜下腔出血过程中的作用尚未完全阐明。发现蛛网膜细胞对脑血管疾病的康复有一定的促进作用。为了阐明蛛网膜细胞的转录调控机制，我们进行了全面的转录分析和表观遗传学分析。我们发现一些组蛋白修饰发生了动态变化，提示蛛网膜细胞染色质动力学的重要性。根据该项目的结果，目前正在进行进一步的研究，以确认和验证这些发现的重要性。

It is not fully elucidated the role of arachnoid cells in the course of subarachnoid hemorrhage. It was found that arachnoid cells could contribute to the recovery from cerebrovascular diseases. To elucidate the transcriptional regulation mechanism of arachnoid cells, we performed comprehensive transcriptional analysis followed by epigenetic analysis. We found some of histone modifications were dynamically changed, suggesting the importance of chromatin dynamics of arachnoid cells. Based on the outcome of this project, further study is now ongoing to confirm and validate the significance of these findings.