Development of imaging system of follicles in mouse ovary using optical coherence tomography

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Optical coherence tomography (OCT) is analogous to ultrasound imaging except that it uses light instead of sound. OCT can provide a depth resolution of 1-20 um, which is one to two orders of magnitude higher than that of conventional ultrasound. OCT is a non-contact, non-invasive, fast imaging modality that provides real time, three-dimensional imaging capability. In this study, we examined, to the best of our knowledge, the first study that uses OCT for analysis of the developmental status of follicles in mouse ovary. The OCT image was identified each developmental stage from primary follicle (50 um in diameter) to antral follicle (350 um in diameter) in the ovary of 25.5-day-old mouse. Further we found time-varying OCT signals at the oocytes compared with around tissues.