Species differences in nociceptive transmissions

本研究通过观察痛和镇痛药物对感觉神经元和脊髓伤害性通路的影响，揭示了痛传递的种属差异。在大鼠感觉神经元中，痛觉剂辣椒素和芥子油激活TRP通道。小鼠脊髓伤害性反射电位的电生理特征及吗啡的作用与大鼠相似。生物胺在大鼠和小鼠之间的作用存在一定差异，这表明在脊髓中通过下行抑制性神经元通路的疼痛控制机制存在物种差异。

The effects of algesic and analgesic agents on the sensory neurons and spinal nociceptive pathways were examined to reveal the species differences in pain transmission. In the rat sensory neurons, the algesic agents, capsaicin and mustard oil, activated TRP channels. The electrophysiological features of spinal nociceptive reflex potentials and the effects of morphine in mice were similar to those in rats. Some differences in the effects of biogenic amines between rats and mice were observed, suggesting that there are species differences in pain control mechanisms by descending inhibitory neuronal pathways in the spinal cord.