Species differences in nociceptive transmissions

研究了镇痛剂和镇痛剂对感觉神经元和脊髓伤害性感受通路的影响，揭示了痛觉传递的物种差异。在大鼠感觉神经元中，止痛剂辣椒素和芥子油可激活Trp通道。小鼠脊髓伤害性反射电位的电生理特征及吗啡的作用与大鼠相似。在大鼠和小鼠之间观察到生物胺的作用有一定的差异，这表明在脊髓中通过下行抑制神经元通路来控制疼痛的机制存在物种差异。

The effects of algesic and analgesic agents on the sensory neurons and spinal nociceptive pathways were examined to reveal the species differences in pain transmission. In the rat sensory neurons, the algesic agents, capsaicin and mustard oil, activated TRP channels. The electrophysiological features of spinal nociceptive reflex potentials and the effects of morphine in mice were similar to those in rats. Some differences in the effects of biogenic amines between rats and mice were observed, suggesting that there are species differences in pain control mechanisms by descending inhibitory neuronal pathways in the spinal cord.