The research of neuroimaging in HIV-positive

HIV阳性患者的神经影像学研究

• 批准号: 22791145
• 负责人: ITO Shigeo
• 金额: $ 2.5万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791145/
• 关键词: 脳機能画像; HIV

We performed the research of neuropsychological test and brain MRI(magnetic resonance imaging） in HIV（human immunodeficiency virus）-positive who have no psychiatric and neurological symptoms and healthy subjects. The MRI study of brain volume was used by the VBM (Voxel-Based-Morphometry) method. Without differences between the two groups in screening tests, HIV-positive group was decreased executive function, behavioral activation system and mood modulation in detailed neuropsychological tests. There were no significant difference at the gray matter and the white matter, compared between groups of the brain volumes in MRI, but the findings suspected by neuronal-degeneration causing to HIV may become an indicator of the AIDS（acquiredimmunodeficiency syndrome）.

我们对无精神和神经症状的HIV（人类免疫缺陷病毒）阳性者和健康受试者进行了神经心理测试和脑MRI（磁共振成像）研究。脑体积的MRI研究采用VBM（Voxel-Based-Morphometry）方法。两组在筛选测验中无差异，但在详细的神经心理测验中，HIV阳性组执行功能、行为激活系统和情绪调节功能下降。MRI脑体积各组间比较，灰质和白色物质无显著性差异，但这些疑似HIV所致神经元变性的表现可能成为AIDS（获得性免疫缺陷综合征）的一个指标。