Production of human liver cytochrome P-450 by using a biotechnological method and development of the clinical application
Production of human liver cytochrome P-450 by using a biotechnological method and development of the clinical application
批准号:
60870095
负责人:
KATO Ryuichi
金额:
$6.27万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research
财政年份:
1985
资助国家:
日本
项目状态:
已结题
起止时间:
1985 至 1986
中文摘要
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英文摘要
Cytochrome P-450 plays an important role in detoxification of drug and other xenobiotics. To develop the medical use of the enzyme, we have investigated the structures of human liver cytochrome P-450 which provide the basis for the production by a genetic engineering methodology informationf of a major human liver cytochrome P-450 was obtained from <lambda> gtll pharge cDNA livrary by the use of the specific antibodies.
期刊论文(3)
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科研奖励(0)
会议论文
Kawano, S., Kamataki, T., Yasumori, T., Yamazoe, Y. and Kato, R.: "Purification of human liver cytochrome P-450 catalyzing testosterone 6 <beta> -hydroxylation." J. Biochem.
Kawano, S.、Kamataki, T.、Yasumori, T.、Yamazoe, Y. 和 Kato, R.:“催化睾酮 6 β-羟基化的人肝细胞色素 P-450 的纯化”。
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作者:
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通讯作者:
Yasumori, T., Kawano, S., Nagata, K., Shimada, M., Yamazoe, Y. and Kato, R.: "Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form." J. Biol. Chem.
Yasumori, T.、Kawano, S.、Nagata, K.、Shimada, M.、Yamazoe, Y. 和 Kato, R.:“与大鼠雄性特定形式相关的人肝细胞色素 P-450 的核苷酸序列。”
DOI:
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作者:
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通讯作者:
Crystallography of membrane protein complex by S-SAD method
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批准号:15K14468
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2015
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负责人:KATO Ryuichi
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依托单位:
Structural and functional study of enzymes which are related to central nervous system disorders with muscle deficiency
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批准号:20370053
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.73万
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财政年份:2008
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负责人:KATO Ryuichi
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依托单位:
Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase
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批准号:05557120
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$9.86万
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财政年份:1993
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负责人:KATO Ryuichi
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依托单位:
Analysis of human interindividual and racial differeness of drug response and metabolism : Approach by the method of diagnosis by gene analysis
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批准号:05454153
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.29万
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财政年份:1993
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负责人:KATO Ryuichi
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依托单位:
Assessment of human drug metabolism by expression of cytochrome P-450 in yeasts.
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批准号:03557113
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$9.73万
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财政年份:1991
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负责人:KATO Ryuichi
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依托单位:
Regulation of expression of cytochrome P-450 by hormonal factor in primary cultured rat hepatocytes.
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批准号:02404025
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$17.92万
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财政年份:1990
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负责人:KATO Ryuichi
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依托单位:
Simultaneous Monitoring of Intracellular Calcium Concentration and Catecholamine Release from Superfused PC 12 Cells and Adrenal Chromaffin Cells Cultured on Microcarrier Beads.
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批准号:01870011
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
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资助金额:$6.4万
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财政年份:1989
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负责人:KATO Ryuichi
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依托单位:
Menbrane phospholipase c activation and signal transduction in relation to change of receptor-linkage mechanism
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批准号:62480123
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.71万
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财政年份:1987
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负责人:KATO Ryuichi
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依托单位:
Molecular mechanism of development and regulation of sex-specific cytochrome P-450 in rat liver
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批准号:59440027
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$12.8万
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财政年份:1985
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负责人:KATO Ryuichi
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依托单位:
国内基金
海外基金
双污泥短程脱氮特性及AOB与NOB菌群分析和调控
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批准号:50608001
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项目类别:青年科学基金项目
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资助金额:26.0万元
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批准年份:2006
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负责人:曾薇
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依托单位: