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Production of human liver cytochrome P-450 by using a biotechnological method and development of the clinical application

Production of human liver cytochrome P-450 by using a biotechnological method and development of the clinical application
生物技术方法生产人肝细胞色素P-450及其临床应用进展
批准号:
60870095
负责人:
KATO Ryuichi
金额:
$6.27万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research
财政年份:
1985
资助国家:
日本
项目状态:
已结题
起止时间:
1985 至 1986

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中文摘要
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英文摘要
Cytochrome P-450 plays an important role in detoxification of drug and other xenobiotics. To develop the medical use of the enzyme, we have investigated the structures of human liver cytochrome P-450 which provide the basis for the production by a genetic engineering methodology informationf of a major human liver cytochrome P-450 was obtained from <lambda> gtll pharge cDNA livrary by the use of the specific antibodies.
期刊论文(3)
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会议论文
Kawano, S., Kamataki, T., Yasumori, T., Yamazoe, Y. and Kato, R.: "Purification of human liver cytochrome P-450 catalyzing testosterone 6 <beta> -hydroxylation." J. Biochem.
Kawano, S.、Kamataki, T.、Yasumori, T.、Yamazoe, Y. 和 Kato, R.:“催化睾酮 6 β-羟基化的人肝细胞色素 P-450 的纯化”。
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通讯作者:
Yasumori, T., Kawano, S., Nagata, K., Shimada, M., Yamazoe, Y. and Kato, R.: "Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form." J. Biol. Chem.
Yasumori, T.、Kawano, S.、Nagata, K.、Shimada, M.、Yamazoe, Y. 和 Kato, R.:“与大鼠雄性特定形式相关的人肝细胞色素 P-450 的核苷酸序列。”
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Crystallography of membrane protein complex by S-SAD method
Structural and functional study of enzymes which are related to central nervous system disorders with muscle deficiency
Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase
  • 批准号:
    05557120
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
  • 资助金额:
    $9.86万
  • 财政年份:
    1993
  • 负责人:
    KATO Ryuichi
  • 依托单位:
Analysis of human interindividual and racial differeness of drug response and metabolism : Approach by the method of diagnosis by gene analysis
  • 批准号:
    05454153
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 资助金额:
    $4.29万
  • 财政年份:
    1993
  • 负责人:
    KATO Ryuichi
  • 依托单位:
国内基金
海外基金
双污泥短程脱氮特性及AOB与NOB菌群分析和调控
  • 批准号:
    50608001
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    26.0万元
  • 批准年份:
    2006
  • 负责人:
    曾薇
  • 依托单位: