Development and Its application of Calcium Phosphate Glass-Ceramics for biomaterials

生物材料用磷酸钙微晶玻璃的研制及其应用

• 批准号: 61850141
• 负责人: ABE Yoshihiro
• 金额: $ 2.62万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61850141/
• 关键词: Calcium phosphate; Glass-ceramics; Impalntation; Artificial bone; Artificial dental crown; CaO-TiO_2-P_2O_5,CaO-P_2O_5; CaO-P_2O_5系; 体積結晶化; 一方向結晶化; 多孔質結晶化ガラス; CaO-TiO_2-P_2O_5結晶化ガラス; 多孔質リン酸カルシウム結晶化ガラス; リン酸カルシウム; 結晶化ガラス; 核形成剤; 配向結晶化

The purpose of this investigation is to develop new calcium phosphate glass-ceramics for sugical and dental use, and to examine how they are biocompatible or not when implanted. Two kinds of glass-ceramics have been developed; one is unidirectionally crystallized CaO-P_2O_5 glass-ceramics, and the other is randomly crystallized glass-ceramics based on mainly calcium phosphate.(1). The unidirectionally crystallized glass-ceramics exhibit high bending strength and high toughness, and good bonding properties with natural bone. We believe that bone implant materials should have low Young's modulus as nearlly as natural bone's; from this view point, the unidirectionally crystallyzed glass-ceramics are to be preferable. However, they have weak points in that chemical durability is not so high to be decreased in mechanical strength with increasing time.(2). The randomly crystallized glass-ceramics in the system of CAO-A1_2O_3-P_2O_5 and CaO-TiO_2-P_2O_5 have high precise castability(shapability) when cast from the molten state. These are suitable for artificial dental crown materials, because of its high shapability, high mechanical strength,as well as high chemical durability. Micro-porous glass-ceramics have been developed by leaching with acid Na_2O-CaO-TiO_2-P_2O_5 glass-ceramics.(3). Biocompatibility has been examined for calcium phosphate glass-ceramics by medical researchers.

这项研究的目的是开发新的磷酸钙玻璃陶瓷，用于舒适和牙齿的使用，并检查植入时它们的生物相容性与否。已经开发了两种玻璃陶瓷。一种是单向结晶的CAO-P_2O_5玻璃陶瓷，另一个是基于主要磷酸钙的随机结晶的玻璃陶瓷。（1）。单向结晶的玻璃陶瓷表现出高弯曲强度和高韧性，并且具有天然骨骼的良好粘结特性。我们认为，骨骼植入物材料的模量应像天然骨一样接近。从这个角度来看，优选的单向晶体玻璃陶瓷是可取的。但是，它们具有弱点，因为随着时间的增加，机械强度的化学耐用性并不高。（2）。 CAO-A1_2O_3-P_2O_5和CAO-TIO_2-P_2O_5的系统中随机结晶的玻璃陶瓷具有高精确的可施；这些适用于人造牙冠材料，因为其高可塑性，高机械强度和高化学耐用性。微孔玻璃陶瓷是通过用酸Na_2o-Cao-tio_2-p_2o_2o_2玻璃陶瓷浸出来开发的。（3）。医学研究人员已经检查了磷酸钙玻璃陶瓷的生物相容性。

项目成果

A.Watanabe;M.Mitsudon;S.Kihara;Y.Abe: Journal of the American Ceramic Society. 72. (1989)

A.Watanabe；M.Mitsudon；S.Kihara；Y.Abe：美国陶瓷学会杂志。

Y.Abe;H.Hosono;M.Hosoe;S.Tsutsumi;A.Shinya;S.Yokozuka: Proceedings of the International Symposium on Bioceramics 188(1988). (1988)

Y.Abe；H.Hosono；M.Hosoe；S.Tsutsumi；A.Shinya；S.Yokozuka：国际生物陶瓷研讨会论文集 188（1988）。

和田真: Orthopaedic Ceramic Implants. 5. 201-205 (1986)

和田诚：骨科陶瓷植入物。5. 201-205 (1986)

長瀬満雄,藍原繁彦,千木良正機,宇田川英一,阿部良弘: Orthopaedie Ceramic Implants. 8. (1989)

Mitsuo Nagase、Shigehiko Aihara、Yoshiki Chigira、Eiichi Udakawa、Yoshihiro Abe：骨科陶瓷植入物 8. (1989)。

A.Watanabe: Journal of the American Ceramic Society. 72. (1988)

A.Watanabe：美国陶瓷学会杂志。