Development of the heat tolerant rat strain and its hybrids for physiological research of adaptaion

目前的项目由以下三个部分组成。（1）一个耐热大鼠菌株的发展我已经有了一个发育良好的耐热大鼠殖民地。在殖民地里，老鼠被选定为长期的高温耐受性和感染，并持续了3年。The Inbred Strain已经发展起来了。据报道，1982年和1988年有20根菌株中最热的耐受性。F1、F2和bc之间的热耐受性在Inbred和ACI大鼠之间，是不耐受热量的一种，是为了遗传分析而确定的。热耐受性是由多基因控制继承的。几种主要基因都被认为是为了在一个炎热的环境中贡献热调节机制。这是必要的，为了更进一步的进步而感到鼓舞。（2）Hybrids Recombinant Inbreds （RI）已确定。大多数RI被废除的原因是实验室中的临时性恶劣条件用于研究。只有一个RI被遗忘并被用于不列颠哥伦比亚省的发展，以防止热浪的爆发。不列颠哥伦比亚省被认为是一种控制性的紧张关系。今天，我开始开发更多的RI以实现更大的进步。（3）关于热耐受性的生理学研究表明，对大鼠的过敏性更强，更积极的老鼠在炎热的环境中被抑制，身体水经济学更高。耐高温大鼠的殖民温度比现有的直线低1 ° C。殖民地温度也在40 ° C附近设置，以响应剧烈的热量暴露。

The present project is consisted of three parts described below.(1) Development of a heat tolerant rat strain I had already a developing heat tolerant rat colony 3 years ago. Rats in the colony were selected in term of heat tolerance and inbred for further 3 years. The inbred strain has been developed. The inbred strain was most heat tolerant among 20 strains reported in 1982 and 1988. Heat tolerance of F1, F2 and bc between the inbred and ACI rats, which were one of heat intolerant strains, were determined for genetic analyses. Heat tolerance was inherited with polygenic control. Several main genes were suggested to contribute to thermoregulatory mechanisms in a hot environment. It is necessary to purify the inbred for further progress.(2) Development of hybrids Recombinant inbreds (RI) were established. The most RI were abolished because of temporary poor condition for research in the laboratory. Only one RI was remined and used for development of BC to the heat tolerant inbred. The BC is expected to be used as a control strain. Today, i begin to develop many RI for further progress.(3) Physiological research on heat tolerance The more heat tolerant the rat strain was, the more actively rats salivated in a hot environment and the higher the body water economics was. Colonic temperature of the heat tolerant rat was 1゜C lower in thermoneutral zone than the existing strains. Colonic temperature also was set near 40゜C in response to acute heat exposure.