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Changes in brain and salivary glands during hyperthermia and genotypic resistance adaptation to heat.

高温期间大脑和唾液腺的变化以及基因型对热的抵抗力适应。

基本信息

批准号：
05670072
负责人：
FURUYAMA Fujiya
金额：
$ 1.34万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670072/
关键词：
body temperature regulation heat resistance rats stress cold resistance inbred hyperthermia adaptation hyperthermia body temperature cell injury brain salivary glands inbred rats FOK genotypic adaptation resistance adaplation

项目摘要

I.Further purification of the FOK rat strainFOK rats had been selected by heat resistance and sibmated up to 40th generation in total. On the other hand, FOK rats were born by caesarean section into disinfected vinylene-isolator. They were gave milk by SPF foster mother. It was demonstrated by quarantine that pups had no specific pathogens. Thus, it became possible to keep FOK rat as a SPF animal and send it safely to other institute.II.The effects of hyperthermiaDuring hyperthermia higher than 40ﾟC,common rats salivate. FOK rats secreted saliva for 300 min in spite of severe dehydration, although other rats secreted small amount of saliva only for 30-120min. On the other hand, at 33ﾟC body temperature in FOK rat was lower than those in other rat strains, although these rats did not salivate in response to heat. Thermogenesis in brown adipocyte in FOK rat was lower during hyperthermia in vitro than those in other rat strains. These findings suggested possible mechanism contributing to diminish body temperature rising in FOK rat besides thermal salivation. Dark neurons were found in ischemic areas and other areas distant from ischemic areas.III.Congenital changes in consequence of genetic resistance adaptation to heatAt 24ﾟC body temperature in FOK rat was lower than those in other rat strains. Submandibular salivary glands in FOK rat were enlarged. FOK rat was also cold resistant rat.

1 .进一步纯化FOK大鼠菌株，通过耐热性选择了FOK大鼠，共繁殖到第40代。另一方面，在消毒的乙烯隔离器中剖腹产出生的FOK大鼠。它们是由SPF的养母喂养的。通过检疫证明幼崽没有特定的病原体。因此，可以将FOK大鼠作为SPF动物，并安全地送到其他研究所。2 .高温的影响在高于40ºC的高温下，普通大鼠会分泌唾液。FOK大鼠严重脱水后仍能分泌唾液300 min，而其他大鼠仅分泌少量唾液30-120min。另一方面，在33ºC时，FOK大鼠的体温低于其他大鼠，尽管这些大鼠对热没有反应。体外热疗过程中，FOK大鼠棕色脂肪细胞的生热作用明显低于其他大鼠品系。这些发现提示除热唾液作用外，抑制FOK大鼠体温升高的可能机制。在24ºC体温下，FOK大鼠比其他品系的大鼠体温低。FOK大鼠下颌下唾液腺肿大。FOK大鼠也是抗寒大鼠。