Studies on physiological characteristics of an inbred rat with resistance adaptation to heat and searches for related-genes

本研究对近交系FOK大鼠的耐热适应特性进行了研究，并寻找了相关基因。此外，对照品系大鼠的脑损伤*手术切除的唾液腺灌流。有证据表明，蒸发冷却是由中枢神经系统负反馈调节的。FOK大鼠对热以外的其他压力表现出有趣的反应。FOK大鼠对心理应激和脂多糖反应较强，发热较大。我们之前曾报道过FOK大鼠具有耐寒能力。在目前的研究中，一种激素在冷暴露的FOK大鼠中显著增加。应用基因芯片技术寻找FOK大鼠下丘脑中先天表达的基因。三个基因被认为在FOK大鼠的下丘脑中高表达。这些发现被认为对在各种情况下的强烈应激条件下的卫生保健是有益的。

We studied the characteristics of the inbred FOK rat with genotypic resistance adaptation to heat and related-genes were searched. In addition, brain injury in control strain of rats *erfusion of surgically extirpated salivary glands. The evidence suggested that evaporative cooling was regulated with mode of negative feedback control by central nervous system. FOK rats showed interesting responses to other stresses than heat. FOK rats largely responded to psychological stress and lipopolysaccharide with large fever. We previously reported that FOK rats were cold resistant. In the present study, a hormone largely increased in cold-exposed FOK rats. Genes which are congenitally expressed in the hypothalamus of FOK rats were searched using cDNA MicroArray analysis. Three genes thought to be highly expressed in the hypothalamus of FOK rats. These findings thought to be beneficial for health care in strongly stressed condition in various situations.