Studies on characteristics of the FOK rat, selected for heat tolerance and inbred, for the purpose of multiple use.

研究FOK大鼠的特性，选择耐热性和近交系，以达到多种用途。

• 批准号: 07557190
• 负责人: FURUYAMA Fujiya
• 金额: $ 2.62万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557190/
• 关键词: the FOK rat; body temperature regulation; heat adaptation; heat resistance; cold resistance; superior salivatory nucleus; salivation; brown adipose tissue; FOK rat,inbred; Body Temperature Regulations; Submandibular Gland; the FOK rat; genotyp

AIM The FOK rat had been selected for heat tolerance and inbred.In the preseent study, it was aimed to study a wide range of characteristics of the FOK rat for the purpose of multiple use the inbred as an experimental animal.RESULTS1.FOK rats secreted highly larger amount of saliva in response to heat from subman dibular glands than the other strains. It was suggested that the thermal salivation is induced by signals come from hypothalamus-superior salivatory nucleus to subman dibular gland. Subman dibular gland of the FOK rat was larger than those of the other strains.2.Thermo genesis in brown adipocytes of the FOK rat was not activated at 37.0ﾟC and 39.9ﾟC by a low concentraition of b-agon ist (10^<-9> M isoproterenol) by which it was activated in the other strains.3.In the thermo neutral zone, thermo effector thresh olds and preferred ambient temperature was lower in the FOK rat than those in the other strains.4.The FOK rat was resistant to cold environment.CONCLUSION The heat resistant FOK rats were also cold resistant and significantly different from other stains in the thermo neutral zone. It can be expected for the FOK rat to be a experimental animal model for multiple use.

FOK大鼠是一种耐热性优良的近交系大鼠，本研究旨在研究FOK大鼠的多种特性，为进一步利用该近交系大鼠作为实验动物提供依据。提示热性流涎是由下丘脑-上唾液核传入下颌下腺的信号引起的。2. FOK大鼠棕色脂肪细胞的产热在37.0 ℃和39.9 ℃下不被低浓度的β-受体激动剂（10 μ M异丙肾上腺素）激活，而在其他品系中被激活<-9>。FOK大鼠的热效应奥尔兹和最适环境温度均低于其他品系; 4. FOK大鼠对寒冷环境具有抵抗力。在热中性区的其他污渍。FOK大鼠有望成为一种多用途的实验动物模型。

项目成果

紫藤 治: "Thermoeffector thresholds and preferred ambient temperatures of the FOK rat." Amer.J.Physiol.(in press).

Osamu Shito：“FOK 大鼠的热效应器阈值和首选环境温度。”Amer.J.Physiol。（正在出版）。

杉本 直俊: "Heat loss responses to acute loads in the FOK rats" Ann.New York Acad.Sci.813. 644-645 (1997)

Naotoshi Sugimoto：“FOK 大鼠对急性负荷的热损失反应”Ann.New York Acad.Sci.813 (1997)。

Furuyama, F., T.Oiwa, and H.Nishino.: Thermo regulation, under moderate heat, of an inbred rat genetically resistant ot severe heat. In : Body Temperature and Metabolism, eds.Nagasaka, T.and Milton, A.S.International Press Editing Center Incorporation, To

Furuyama, F., T.Oiwa, 和 H.Nishino.：在中等热量下，遗传抵抗严重高温的近交大鼠的温度调节。

古山富士弥: "Differences in thermal salivation between the FOK rat Ca model of genotypic heat adaptation and three other rat strains" Physiol.& Behav.(in press).

Fujiya Furuyama：“基因型热适应 FOK 大鼠 Ca 模型与其他三种大鼠品系之间热流涎的差异”Physiol.& Behav.（出版中）。

田中越郎: "Regulation of Heat Production of Brown Adipocytes via Typical and A Typical β-Adrenoceptors in the Rat" Jpn.J.Physiol. 45. 1043-1051 (1995)

Koshiro Tanaka：“通过大鼠中典型和典型 β-肾上腺素受体调节棕色脂肪细胞的产热”Jpn.J.Physiol. 45. 1043-1051 (1995)