Studies on characteristics of the FOK rat, selected for heat tolerance and inbred, for the purpose of multiple use.

目的FOK大鼠是一种耐热近交系大鼠。本研究旨在研究FOK大鼠的多种特性，以便将近交系FOK大鼠作为实验动物。结果1.FOK大鼠对亚颌下腺的热反应分泌的唾液比其他品系大得多。提示热唾液是由下丘脑-上唾液核传入亚人类颌下腺的信号引起的。2.在37.0ﾟC和39.9ﾟC下，低浓度的b-Agon ist(10^&lt；-9&gt；3.在热中性区，FOK大鼠的热效应阈值和喜好环境温度低于其他品系。4.FOK大鼠对寒冷环境具有耐受性。结论耐热FOK大鼠也具有较强的耐寒性，与其他品系的FOK大鼠有显著差异。可以预期，FOK大鼠将成为一种多用途的实验动物模型。

AIM The FOK rat had been selected for heat tolerance and inbred.In the preseent study, it was aimed to study a wide range of characteristics of the FOK rat for the purpose of multiple use the inbred as an experimental animal.RESULTS1.FOK rats secreted highly larger amount of saliva in response to heat from subman dibular glands than the other strains. It was suggested that the thermal salivation is induced by signals come from hypothalamus-superior salivatory nucleus to subman dibular gland. Subman dibular gland of the FOK rat was larger than those of the other strains.2.Thermo genesis in brown adipocytes of the FOK rat was not activated at 37.0ﾟC and 39.9ﾟC by a low concentraition of b-agon ist (10^<-9> M isoproterenol) by which it was activated in the other strains.3.In the thermo neutral zone, thermo effector thresh olds and preferred ambient temperature was lower in the FOK rat than those in the other strains.4.The FOK rat was resistant to cold environment.CONCLUSION The heat resistant FOK rats were also cold resistant and significantly different from other stains in the thermo neutral zone. It can be expected for the FOK rat to be a experimental animal model for multiple use.