Trial manufacture of visual field specific stimulator by means of computer image frame memory and an application to brain metabolic mapping.

利用计算机图像帧存储器试制视野特异性刺激器并应用于脑代谢图谱。

基本信息

批准号：
63870007
负责人：
MIYASHITA Yasushi
金额：
$ 2.82万
依托单位：
University of Tokyo, Faculty of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

We obtained two major results in this research project; first was to manufacture a visual stimulator and to show its effectiveness in an electrophysiological single-unit recording. Second was to apply it to the metabolic mapping of the brain.We had already shown merits of using "fractal patterns" in the research of visual memory. In this project our visual stimulator was constructed by modifying the FBX24 (Texnai) image frame memory system. The stimulator utilized the zoom, pan and scroll functions of FBX24 and succeeded in generating fractal patterns and presenting them at any position of the visual field in any size within 17msec. By using this stimulator we found that a shape-selective neural activity in the temporal cortex was highly selective for the pictorial information and was independent of the physical attributes such as size, orientation, color or position of the presented stimulus. In the hippocampus we found neuronal activity related to the place in which a stimulus was shown. This finding supports the hypothesis that the hippocampus contributes to the place memory. In the second application to metabolic mapping of the brain, local glucose utilization rates (LGU) were measured by 2-deoxyglucose autoradiography method after unilateral visual stimulation. We found that the cerebellar flocculus, especially in the contralateral side, exhibited high LGU during the visual stimulation. In the middle one-third of the contralateral flocculus we found patch-like high LGU areas, which may correspond to the cerebellar microzones.In 1989 a positron emission tomography (PET) was introduced in the Tokyo University Hospital and the Department of Radiology asked us to modify our visual stimulator for the PET system. It is important to further develop our results for a clinical diagnosis.

我们在该研究项目中获得了两个主要结果。首先是制造视觉刺激器，并在电生理单单元记录中显示其有效性。其次是将其应用于大脑的代谢映射。我们已经显示出在视觉记忆研究中使用“分形模式”的优点。在此项目中，我们的视觉刺激器是通过修改FBX24（TEXNAI）图像框架存储系统来构建的。刺激器利用了FBX24的变焦，锅和滚动功能，并成功地生成了分形图案，并在视野的任何位置以17msec以内的任何大小展示它们。通过使用此刺激器，我们发现颞皮层中的形状选择性神经活动对于图形信息具有很高的选择性，并且与物理属性无关，例如大小，方向，颜色或位置。在海马中，我们发现与刺激显示的位置相关的神经元活性。这一发现支持海马有助于该地点记忆的假设。在大脑代谢图的第二次应用中，单侧视觉刺激后，通过2-脱氧葡萄糖放射摄影方法测量局部葡萄糖利用率（LGU）。我们发现，在视觉刺激期间，小脑絮凝物，尤其是在对侧的侧面表现出高LGU。在中间的三分之一中，我们发现了类似斑块的高LGU区域，可能对应于小脑微唑。在1989年，在东京大学医院引入了正电子发射断层扫描（PET）和放射学系，要求我们修改我们的宠物系统的视觉刺激器。进一步发展临床诊断的结果很重要。