Dynamical mechanisms underlying cognitive memory in primates : Functional analysis of its global network and local circuit

灵长类动物认知记忆的动力机制：全球网络和局部回路的功能分析

• 批准号: 19002010
• 负责人: MIYASHITA Yasushi
• 金额: $ 439.21万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19002010/
• 关键词: 神経科学; 大脳皮質; 記憶; 電気生理; 磁気共鳴機能画像; 局所神経回路; 領野間結合; 画像

We analyzed the neural mechanisms underlying cognitive memory from two view-points : one is a local circuit(or processing unit) that generates and transforms encoding/recall signals, and the other is a global cortical network in which local processing units exchange bottom-up or top-down search signals. We identified many functional global networks using effective connectivity measures in BOLD fMRI. We also found a flexible recruitment of interlaminar connectivity in the local circuit of six-layered association cortices, depending on the cognitive demand. Our study provided a breakthrough in understanding of the operation principles of the primate cerebral cortex for cognitive memory.

我们从两个角度分析了认知记忆的神经机制：一个是产生和转换编码/回忆信号的局部电路（或处理单元），另一个是全局皮层网络，其中局部处理单元交换自下而上或自上而下的搜索信号。我们确定了许多功能性的全球网络使用有效的连接措施，在BOLD功能磁共振成像。我们还发现了一个灵活的招聘层间连接的本地电路的六层联合皮层，这取决于认知需求。本研究为认识灵长类动物大脑皮层认知记忆的运作机制提供了突破。

项目成果

Formation of Long-Term Memory Representation in Human Temporal Cortex Related to Pictorial Paired Associates

人类颞叶皮层中与图像配对相关的长期记忆表征的形成

• 发表时间: 2009
• 期刊: Journal of Neuroscience 29
• 作者: 杉田聡;亀井康富;小川佳宏;杉田聡;杉田聡;越後良介;Masafumi Kameya;亀谷将史;亀谷将史;亀谷将史;亀谷将史;Teppei Tsujita;Atsushi Konno;Teppei Tsujita;辻田哲平;福井類;Rui FUKUI;福井類;Rui FUKUI;渡部喬光;小西清貴;小西清貴;木村紘子;廣瀬聡;近添淳一;山下謙一郎
• 通讯作者: 山下謙一郎

Efficiency of Go/No-Go Task Performance Implemented in the Left Hemisphere

• DOI: 10.1523/jneurosci.0540-12.2012
• 发表时间: 2012-06-27
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Hirose, Satoshi;Chikazoe, Junichi;Konishi, Seiki
• 通讯作者: Konishi, Seiki

Preparation to Inhibit a Response Complements Response Inhibition during Performance of a Stop-Signal Task

• DOI: 10.1523/jneurosci.3645-09.2009
• 发表时间: 2009-12-16
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Chikazoe, Junichi;Jimura, Koji;Konishi, Seiki
• 通讯作者: Konishi, Seiki

Neural correlates of long-term associative memory in human temporal cortex

人类颞叶皮层长期联想记忆的神经相关性

• 发表时间: 2009
• 作者: Konishi;S.;et al.
• 通讯作者: et al.

Brain activities associated with preparation and execution of stopping

与准备和执行停止相关的大脑活动

• 发表时间: 2009
• 作者: Chikazoe;J.;et al.
• 通讯作者: et al.