Dynamical mechanisms underlying cognitive memory in primates : Functional analysis of its global network and local circuit

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We analyzed the neural mechanisms underlying cognitive memory from two view-points : one is a local circuit(or processing unit) that generates and transforms encoding/recall signals, and the other is a global cortical network in which local processing units exchange bottom-up or top-down search signals. We identified many functional global networks using effective connectivity measures in BOLD fMRI. We also found a flexible recruitment of interlaminar connectivity in the local circuit of six-layered association cortices, depending on the cognitive demand. Our study provided a breakthrough in understanding of the operation principles of the primate cerebral cortex for cognitive memory.