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Retrograde sensory ganglionectomy for control of intractable pain

逆行感觉神经节切除术控制顽固性疼痛

基本信息

批准号：
63870063
负责人：
YAMAMOTO Teiji
金额：
$ 6.21万
依托单位：
Fukushima Medical College (1989)Tohoku University (1988)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63870063/
关键词：
pain neuralgia axoplasmic transport doxorubicin sensory evoked potentials trigeminal nerve ganglionectomy

项目摘要

Our earlier studies indicated that several neurotoxins could be retrogradely transported to their parental sensory neurons when intraneurally injected into the peripheral nerve. Consequently, sensory neurons having taken up the toxin underwent degeneration. Utilizing this phenomenon, we initiated a study in which suitable neurotoxins when injected into the nerve may selectively gangliotomize the particular groups of sensory cells in the dorsal root ganglia or trigeminal ganglia and thus serve as a way of controlling pain.Among more than several neurotoxins studied, we found doxorubicin(Adriamycin, ADM) is in particular useful for this purpose since ADM has its proper autofluorescence which enabled us to localize the route and destination of ADM when injected. Within 12 hrs after intraneural injection of ADM into the cat's trigeminal nerve branches, ADM was demonstrated in the trigeminal ganglion cells in a topographically organized manner. Within several days, these neurons having take … More n up ADM underwent selective degeneration. The primary afferents entering into the brainstem trigeminal complex could be traced upt to the spinal trigeminal nucleus by the Fink-Helmer method. The short latency sensory evoked potential (SSEP) of the trigeminal nerve disclosed the abolishment of the entire waveforms 24-48 hrs after the injection of ADM into the corresponding nerve. The SSEP never recovered when once lost.Following these basic data, we initiated the ADM ganglionectomy to three selected patients with intractable neuralgic pain syndrome. Two with postherpetic neuralgia and the third with failed trigeminal neuralgia to a variety of attempts. These patients responded favorably to ADM ganglionectomy. One, complete abolishment of pain, the second, 50 % and the third 70 % relief. Some remaining pain after ADM ganglionectomy in two patients was in part explained by the wider extent of pain which was not totally denervaied by a single injection. This novel method of pain control may be utilized for neuralgic pain syndromes of deafferentation in nature such as postherpetic neuralgia, phantom limb pain, and pain due to cancer invasion into the nerves. Less

我们早期的研究表明，当神经内注射到周围神经时，几种神经毒素可以逆行转运到它们的亲代感觉神经元。因此，吸收了毒素的感觉神经元发生变性。利用这一现象，我们开始了一项研究，在这项研究中，当将合适的神经毒素注射到神经中时，可以选择性地切断背根神经节或三叉神经节中的特定感觉细胞群，从而作为控制疼痛的一种方式。阿霉素（Adriamycin，ADM）对于该目的特别有用，因为ADM具有其适当的自体荧光，这使得我们能够在注射时定位ADM的途径和目的地。在猫三叉神经分支神经内注射ADM后12小时内，ADM在三叉神经节细胞中以拓扑学组织化的方式被证明。几天之内，这些神经元 ...更多信息 ADM组选择性变性。用Fink-Helmer法可将进入脑干三叉神经复合体的初级传入纤维追踪至三叉神经脊束核。三叉神经短潜伏期感觉诱发电位（SSEP）显示ADM注入后24-48小时，三叉神经短潜伏期感觉诱发电位（SSEP）全部消失。根据这些基本资料，我们选择了三位患有顽固性神经痛综合征的病人，进行ADM神经节切除术。两个带状疱疹后神经痛和三叉神经痛失败的第三种尝试。这些患者对ADM神经节切除术反应良好。第一种是完全消除疼痛，第二种是减轻50%，第三种是减轻70%.两名患者接受ADM神经节切除术后仍存在一些疼痛，部分原因是疼痛程度更广，单次注射并未完全消除神经支配。这种新的疼痛控制方法可用于神经痛性疼痛综合征的传入神经阻滞的性质，如带状疱疹后神经痛，幻肢痛，疼痛由于癌症侵入神经。少