Proteomics subtyping and circadian dynamics of PDACs to develop novel therapeutic strategies (P11)

点击翻译按钮获取中文摘要

We will comprehensively study the proteome and phosphoproteome of genetically defined PDAC subtypes over time to achieve mechanistic insights into the cellular metabolism and signaling pathway networks driven by the circadian clock and different oncogenic mutations such as KrasG12D, KrasG12D/Trp53R172H, BrafV637E and Pik3caH1047R. The functional characterization of PDAC subtype specific candidate targets obtained from our proteomics/phosphoproteomics and circadian studies will allow us to pinpoint cancer markers and novel drug targets with the goal to develop subtype-specific chronotherapeutic treatment strategies for this devastating disease.