Discovery and characterization of a pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the CNS.
中枢神经系统突触前末梢压力感觉和转导 (PREST) 机制的发现和表征。
基本信息
- 批准号:21K15203
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Early-Career Scientists
- 财政年份:2021
- 资助国家:日本
- 起止时间:2021-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We announced mechanical transmission and PREST in CNS in 2021 (Ucar et al., Nature, 2021).I am studying the underlying mechanisms of PREST and we published a review article to underline its physiological importance for brain function and memory.Recently I found that mechanical stimulation activates intracellular signaling pathways which lead to synaptic vesicle regulation during PREST. Here, synaptic vesicle clusters are mobilized upon mechanical stimulation and this is estimated to be regulated by a kinase pathway that I am working on.
我们在2021年宣布了CNS中的机械传动和PREST(Ucar等人,Nature,2021)。我正在研究PREST的潜在机制,我们发表了一篇综述文章,强调其对大脑功能和记忆的生理重要性。最近我发现机械刺激激活细胞内信号通路,导致PREST期间的突触囊泡调节。在这里,突触囊泡簇在机械刺激下被动员,据估计这是由我正在研究的激酶途径调节的。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mechanosensation and PREST in the presynaptic terminals
突触前末梢的机械感觉和 PERST
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Hasan Ucar;Satoshi Watanabe;Jun Noguchi;Sho Yagishita;Yuichiro Morimoto;Noriko Takahashi;Haruo Kasai
- 通讯作者:Haruo Kasai
Mechanical actions of dendritic-spine enlargement and the discovery of the PREST mechanism in the presynaptic terminals in the CNS
树突棘增大的机械作用和中枢神经系统突触前末梢 PERST 机制的发现
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Kasai;H. & Ucar;H.;Ucar Hasan;Ucar Hasan
- 通讯作者:Ucar Hasan
Presynaptic terminals can sense spine enlargement and mechanical pressure to provide stronger synaptic transmission
突触前末梢可以感知脊柱增大和机械压力,以提供更强的突触传递
- DOI:
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Hasan Ucar;Satoshi Watanabe;Jun Noguchi;Sho Yagishita;Yuichiro Morimoto;Noriko Takahashi;Haruo Kasai
- 通讯作者:Haruo Kasai
Mechanosensing of the enlargement of dendritic spines by presynaptic terminals in rat hippocampus
大鼠海马突触前末梢树突棘增大的机械传感
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Kasai;H. & Ucar;H.;Ucar Hasan;Ucar Hasan;Ucar Hasan
- 通讯作者:Ucar Hasan
Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis
- DOI:10.1038/s41586-021-04125-7
- 发表时间:2021-11
- 期刊:
- 影响因子:64.8
- 作者:H. Ucar;Satoshi Watanabe;J. Noguchi;Yuichi Morimoto;Y. Iino;Sho Yagishita;N. Takahashi;H. Kasai-
- 通讯作者:H. Ucar;Satoshi Watanabe;J. Noguchi;Yuichi Morimoto;Y. Iino;Sho Yagishita;N. Takahashi;H. Kasai-
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