Discovery and characterization of a pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the CNS.

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We announced mechanical transmission and PREST in CNS in 2021 (Ucar et al., Nature, 2021).I am studying the underlying mechanisms of PREST and we published a review article to underline its physiological importance for brain function and memory.Recently I found that mechanical stimulation activates intracellular signaling pathways which lead to synaptic vesicle regulation during PREST. Here, synaptic vesicle clusters are mobilized upon mechanical stimulation and this is estimated to be regulated by a kinase pathway that I am working on.