Unraveling the differential role of myeloid cells in the regulation of ANCA-induced glomerulonephritis

揭示骨髓细胞在 ANCA 诱导的肾小球肾炎调节中的不同作用

• 批准号: 404613165
• 负责人: Privatdozent Dr. Adrian Schreiber
• 金额: --
• 依托单位: Experimental and Clinical Research Center (ECRC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/404613165?language=en
• 关键词: Unraveling; differential; role; myeloid; cells

The aim of the research proposal is the detailed analysis of the pathogenic contribution of different myeloid subspecies and the identification of a regulatory network between myeloid cells and T-cells in ANCA-induced glomerulonephritis. We and others have shown that both neutrophils and monocytes are activated in vitro by ANCA. However, their contribution to the induction of an ANCA-glomerulonephritis and the specific role of different myeloid subpopulations is not understood. Therefore, we will analyze the contribution of different myeloid subpopulations to ANCA-glomerulonephritis by specific modulation of these subpopulations in two different ANCA-animal models. Furthermore, we will characterize a regulatory network between myeloid cells and adaptive T-cell immunity in ANCA-glomerulonephritis. In addition, we aim to establish a urinary myeloid and T-cell flow-cytometry signature in patients with ANCA-glomerulonephritis. In summary our studies will result in a better understanding of the role of myeloid cells in the pathogenesis of ANCA-glomerulonephritis and their role in the regulation of T-cell immunity.

该研究提案的目的是详细分析不同髓系亚种的致病作用，并确定ANCA诱导的肾小球肾炎中髓系细胞和T细胞之间的调控网络。我们和其他人已经证明中性粒细胞和单核细胞在体外都被ANCA激活。然而，它们对ANCA-肾小球肾炎诱导的贡献以及不同髓系亚群的具体作用尚不清楚。因此，我们将通过在两种不同的ANCA动物模型中对这些亚群的特异性调节来分析不同髓系亚群对ANCA肾小球肾炎的贡献。此外，我们将描述ANCA肾小球肾炎中髓系细胞和适应性T细胞免疫之间的调节网络。此外，我们的目标是建立一个尿髓细胞和T细胞流式细胞术签名与ANCA肾小球肾炎患者。总之，我们的研究将导致更好地了解髓系细胞在ANCA-肾小球肾炎发病机制中的作用及其在T细胞免疫调节中的作用。