Mutual feedback between metabolically active coacervate droplets and nucleic acid catalysts (P16)

代谢活性凝聚液滴与核酸催化剂之间的相互反馈（P16）

• 批准号: 405570873
• 金额: --
• 依托单位: Institute for Advanced Study (IAS)
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405570873?language=en
• 关键词: Mutual; feedback; between; metabolically; active

We will study the synergies between protocell-first and the nucleic acid (NA) first hypotheses by developing a protocell model based on active, complex coacervate droplets consisting of prebiotically plausible cationic peptides and oligonucleotides. In the chemically fueled reaction cycle, the active droplets emerge when chemical energy is available, and decay without. Since part of the components is nucleotide-based, these protocells can contain hereditary information and host catalytic activity. We will focus on effects of droplet microenvironment on the activity and molecular evolution of NA catalysts but also how these catalysts can affect droplet survival and / or proliferation.

我们将研究之间的协同作用，首先和核酸（NA）的第一个假设，通过开发一个原始细胞模型的基础上积极的，复杂的凝聚液滴组成的prebiotically合理的阳离子肽和寡核苷酸。在化学燃料反应循环中，当有化学能时，活性液滴就会出现，而没有化学能时就会衰变。由于部分组分是基于核苷酸的，这些原始细胞可以包含遗传信息和宿主催化活性。我们将专注于液滴微环境对NA催化剂的活性和分子演变的影响，以及这些催化剂如何影响液滴的存活和/或增殖。