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Study on the reconstruction of the mandibular bone using Apatite porous block

磷灰石多孔块重建下颌骨的研究

基本信息

批准号：
62870082
负责人：
OHNISHI Masatoshi
金额：
$ 3.97万
依托单位：
Yamanashi Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

项目摘要

Using animal experiments, the authors have been studying the morphological development of multiporous apatite blocks, and examining the bioaffinity of these blocks in vivo and the state of bone formation.Based on the results of these animal experiments, clinical application of these blocks began in October 1980.The aim of adapting apatite material as a substitute for the jaw bone can be roughly classified into two parts:(1) as a substitute shape, and (2) as a structural support. The former employs the method of planning the recovery and reformation of the bone shape when the extent of loss is small and the shape of the jaw bone needs to be transformed.With this reconstruction method, after segmental resection, the lower jaw bone is left at both ends of the lost part, and in between them a bridge is made with the apatite. The bridge must therefore be fixed securely. Unfortunately, the apatite porous body is fragile, and the nature of the material does not allow it to be wired directly t … More o the mandibular bone. As a result, a frame structure support for the lower jaw bone is created by means of a metal plate reinforcement. For this purpose, we developed a metal plate made of titanium with a structure like that shown in. By screwing down the plate, the apatite block is firmly fixed in place, supported by the pressure welding of the bones from the front and rear, and the plate from outside and underneath.The apatite bone substitute material as artificial living tissue is much easier to handle compared to the transplant of, for example, intestinal bone tissue or costa from living bone tissue for the reconstruction of the lower jaw bone. However, to obtain clinical results which equal reconstruction by living bone tissue using artificial living tissue material, a strict operation system and control are necessary where by maximum utility is achieved by fully considering the biodynamics of the material. For this purpose, it will be necessary to consider an operation that uses artificial bone in the same way as or more deeply than a bone transplant operation using living bone tissue. Less

作者通过动物实验，研究了多孔磷灰石块的形态发育，观察了多孔磷灰石块在体内的生物亲和性和成骨状态。根据这些动物实验的结果，多孔磷灰石块于1980年10月开始临床应用。（1）作为替代形状，以及（2）作为结构支撑。前者是指在颌骨缺损程度较小时，需要改变颌骨形状时，采用有计划的恢复和重建的方法，即在部分切除后，在缺损的两端保留下颌骨，在两者之间用磷灰石做一座桥。因此，桥梁必须牢固地固定。不幸的是，磷灰石多孔体是易碎的，并且材料的性质不允许其直接连接到 ...更多信息下颌骨。结果，通过金属板加强件形成用于下颌骨的框架结构支撑。为此，我们开发了一种由钛制成的金属板，其结构如所示。通过拧紧骨板，磷灰石块被牢固地固定在适当的位置，并通过从前面和后面的骨的压力焊接以及从外面和下面的骨板的压力焊接来支撑。作为人工活组织的磷灰石骨替代材料与例如移植肠骨组织或来自活骨组织的肋骨以重建下颌骨相比，操作容易得多。然而，为了获得等同于使用人工活组织材料通过活骨组织重建的临床结果，严格的操作系统和控制是必要的，其中通过充分考虑材料的生物动力学来实现最大效用。为此，有必要考虑以与使用活骨组织的骨移植手术相同的方式或比使用活骨组织的骨移植手术更深入地使用人造骨的手术。少