Development of highiy bioactive artificial bone by bioactive material anci growth factor

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The purpose of this study is to create an artificial bone that has a comparable bone-forming ability to natural bone by adding growth factors to bioactive ceramics1: Enhancement of bone-bonding ability by TAK-778TAK778 is a newly formed low molecular agent, which may exert regulatory effects on osteoblast differentiation. This agent was applied to the interface between bioactive ceramics and bone at implantation, which demonstrated that TAK-778 enhanced the bone bonding strength of the ceramics2: Absorption of porous AWCylinders of porous AW or porous HA (porosity 70% and mean pore diameter 200 urn for both materials) were implanted into the bone marrow cavity of rabbit femurs, and analyzed chronologically. AW was absorbed continuously, and at 12 months the residual material corresponded to about 30% of the starting material, whereas HA was hardly absorbed. The volume of newly formed bone in the material pores was higher with AW than with HA. AW-bone bonding was maintained during bone remodeling and material absorption. Thus porous AW showed faster absorption and greater bone ingrowth than HA, suggesting better suitability for a carrier of growth factors3: Boneforming ability of AW-b-FGF complexPorous AW cylinders were soaked in the solution of b-FGF under high vacuum and were implanted into rabbit femur. Although more vascular formation into the pores was observed in FGF group than control (AW without b-FGF), the amounts of bone formation were comparable