Multisensory Perception of Self Motion: Psychophysics and Functional Neuroanatomy

自我运动的多感官知觉：心理物理学和功能神经解剖学

• 批准号: 409032223
• 负责人: Professor Dr. Mark Greenlee
• 金额: --
• 依托单位: Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/409032223?language=en
• 关键词: Multisensory; Perception; Self; Motion; Psychophysics

With our sensory systems we experience our environment through touch, hearing, sight, smell and taste. In addition, we have vestibular organs, which inform us about self motion and thus contribute to maintaining balance and posture. Caloric vestibular stimulation will be combined with visual stimulation to analyze the interaction between the visual and vestibular sensory systems in self-motion perception. We want to use these modes of stimulation to study the neural interactions during simulated self motion. For this purpose, congruent and incongruent visual-vestibular stimulus combinations will be used to investigate their influence on the perception of self motion, on direction discrimination of optic-flow fields and on the corresponding neuronal correlates of the self-motion perception. We will measure brain activity in healthy participants using the method of functional magnetic resonance imaging (fMRI).In addition, the method of diffusion-weighted MRI will be used in conjunction with probabilistic fiber tracking to analyze the anatomical connectivity between vestibular and visual cortical regions. By comparing the structural and functional connectivity of the human brain at rest (i.e., resting state), it will be shown how parts of the visual-vestibular network are interconnected.Finally, the suppression of the vestibular cortex will be examined during the processing of visual motion. When attention is focused on moving visual stimuli, activity in the vestibular cortex is suppressed. Our aim is to use the method of repetitive transcranial magnetic stimulation (TMS) and functional MRI to determine the neuronal source of this inhibition in the vestibular cortex. The results of these investigations should provide new insights into the multisensory integration of visual and vestibular information in self-motion perception.

在我们的感觉系统中，我们通过触摸，听力，视觉，气味和味道体验环境。此外，我们还有前庭器官，它会告诉我们自动运动，从而有助于保持平衡和姿势。热量前庭刺激将与视觉刺激相结合，以分析自动感知中视觉和前庭感觉系统之间的相互作用。我们希望使用这些刺激模式来研究模拟自动运动期间的神经相互作用。为此，将使用一致性和不一致的视觉 - 视觉刺激组合来研究它们对自我运动感知的影响，对视流场的方向区分以及自我运动感知的相应神经元相关性的影响。我们将使用功能性磁共振成像（fMRI）的方法来测量健康参与者的大脑活动。此外，扩散加权MRI的方法将与概率纤维跟踪结合使用，以分析前庭和视觉皮质区域之间的解剖连接性。通过比较人脑在休息时的结构和功能连接性（即静止状态），将显示如何相互连接视觉 - 视觉网络的一部分。在视觉运动处理过程中，将检查对前庭皮层的抑制。当注意力集中在移动视觉刺激上时，前庭皮层的活性就会被抑制。我们的目的是使用重复的经颅磁刺激（TMS）和功能性MRI的方法来确定前庭皮质中这种抑制的神经元来源。这些研究的结果应为自我运动感知中视觉和前庭信息的多感觉整合提供新的见解。