Complement-mediated crosstalk between tubular and interstitial cells in renal transplantation - focus on the lectin-activated pathway (C02)

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In this project, we will comprehensively characterize the activation of the complement pathway, in particular of the lectin pathway, during renal transplantation, with specific focus on the crosstalk of renal tubular epithelial cells and inflammatory cells. For this, we will use human renal biopsies and renal tissue from experimental studies in rats. Using either an inhibitory antibody directed against the activator of the lectin-activated complement pathway MASP-2, or a C5-blocker inhibiting the terminal route of all complement pathways, we aim to target complement activation to prevent graft deterioration and graft loss. In addition, interaction of various complement factors with renal tubular cells will be investigated in vitro.