A renal function of 2,3-bisphosphoglycerate mutase (BPGM) (B01)

2,3-二磷酸甘油酸变位酶 (BPGM) 的肾功能 (B01)

• 批准号: 418373858
• 金额: --
• 依托单位: Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418373858?language=en
• 关键词: renal; function; bisphosphoglycerate; mutase; BPGM

BPGM generates 2,3-bisphosphoglycerate (2,3-BPG) to reduce oxygen binding to hemoglobin, and improve tissue oxygenation. We show that in the nephron BPGM is constitutively expressed, and up-regulated under conditions such as acute kidney injury, clear cell renal carcinoma, or knock-out of the tumor suppressor von Hippel Lindau protein. Moreover, hypoxia or osmotic stress up-regulate BPGM in kidney cells in vitro. In renal cells BPGM modulates glucose utilization, promotes scavenging of reactive oxygen species, as well as cell survival under stress. We postulate that BPGM is renoprotective.

BPGM产生2，3-二磷酸甘油酸（2，3-BPG）以减少氧与血红蛋白的结合，并改善组织氧合。我们表明，在肾单位BPGM组成型表达，并上调条件下，如急性肾损伤，透明细胞肾癌，或敲除的肿瘤抑制因子冯希佩尔林道蛋白。此外，缺氧或渗透胁迫上调BPGM在体外肾细胞。在肾细胞中，BPGM调节葡萄糖利用，促进活性氧的清除以及应激下的细胞存活。我们推测BPGM具有肾脏保护作用。