Coordination Funds

协调基金

基本信息

项目摘要

The evolution of complex eukaryotes went along with the need to compartmentalize and separate cellular processes, often in the form of membrane-encapsulated organelles like the nucleus, mitochondria, the endoplasmic reticulum, the Golgi apparatus, endosomes and lysosomes, which have the status of textbook knowledge. Membrane encapsulation was associated with the problem of developing some form of transport system such that biomolecules can exchange between organelles. Other long-known compartments are membraneless organelles, such as nucleoli, stress granules or Cajal bodies. However, only within the last decade it has become clear that these compartments arise from the physical process of phase separation, which bestows them with very special properties; they can be reversible, highly dynamic, and they continuously exchange molecules with their surroundings without the requirement of specific transport systems. These properties require us to rethink the organization of cells and to evolve our existing concepts of compartmentalization and regulation of cellular transport and functions, setting the stage for ‘cell biology 2.0’. To investigate these newly emerging concepts and elucidate the mechanisms that underlie cellular compartmentalization via phase separation and regulation thereof, we also need to develop new tools and approaches and combine cell biology and biophysics with biochemical reconstitution as well as theory and modelling. This combination of disciplines will allow us to make testable predictions about the role of phase separation in diverse biological processes, which will be validated in relevant functional biochemical assays as well as cell biological, developmental and disease models. The last ten years of phase separation research have only scratched the surface of the complexity of biomolecular condensates. The initial excitement about the role of phase separation has recently been extended to include more solid types of condensates which enable additional layers of functional regulation. This national priority program brings together scientists from diverse fields, thinking environments and scientific backgrounds. This network will allow researchers to synergistically decipher how novel functions, but also pathologies, emerge from the process of condensation, and what molecular underpinnings facilitate and regulate this key process. By doing so, this program will nourish a new generation of scientists who challenge the boundaries of existing fields and tackle important emerging problems in the life sciences through the lens of condensates.
复杂的真核生物的进化沿着需要划分和分离细胞过程,通常以膜包封的细胞器的形式,如细胞核、线粒体、内质网、高尔基体、内体和溶酶体,它们具有教科书知识的地位。膜包封与开发某种形式的运输系统的问题有关,这样生物分子可以在细胞器之间交换。其他长期已知的隔室是无膜细胞器,例如核仁、应激颗粒或卡哈尔体。然而,只有在过去的十年中,人们才清楚地认识到这些隔室是由相分离的物理过程产生的,这赋予了它们非常特殊的性质;它们可以是可逆的,高度动态的,并且它们与周围环境连续交换分子,而不需要特定的运输系统。这些特性要求我们重新思考细胞的组织,并发展我们现有的细胞运输和功能的划分和调节概念,为“细胞生物学2.0”奠定基础。为了研究这些新出现的概念并阐明通过相分离及其调节的细胞区室化的机制,我们还需要开发新的工具和方法,并将联合收割机细胞生物学和生物物理学与生化重建以及理论和建模相结合。这种学科的结合将使我们能够对相分离在不同生物过程中的作用进行可测试的预测,这些预测将在相关的功能生化分析以及细胞生物学,发育和疾病模型中得到验证。过去十年的相分离研究只是触及了生物分子凝聚物复杂性的表面。最初对相分离作用的兴奋最近已经扩展到包括更多固体类型的冷凝物,这些冷凝物能够实现功能调节的附加层。这个国家优先计划汇集了来自不同领域,思维环境和科学背景的科学家。该网络将使研究人员能够协同破译新功能以及病理如何从冷凝过程中出现,以及什么样的分子基础促进和调节这一关键过程。通过这样做,该计划将培养新一代的科学家,他们挑战现有领域的界限,并通过冷凝物的透镜解决生命科学中重要的新兴问题。

项目成果

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会议论文数量(0)
专利数量(0)

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Professor Dr. Edward A. Lemke其他文献

Professor Dr. Edward A. Lemke的其他文献

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{{ truncateString('Professor Dr. Edward A. Lemke', 18)}}的其他基金

Specific labeling of proteins within living cells with single residue precision through genetically encoded click chemistry
通过基因编码的点击化学以单残基精度对活细胞内的蛋白质进行特异性标记
  • 批准号:
    223208190
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes
"Unfolding" the Nucleo-Cytoplasmic Transport Machinery one molecule at a time
一次一个分子地“展开”核-细胞质运输机制
  • 批准号:
    157900825
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Independent Junior Research Groups
A genetically encoded ASAXS ruler to study the dimension of intrinsically disordered proteins
基因编码的 ASAXS 标尺,用于研究本质无序蛋白质的尺寸
  • 批准号:
    432343117
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Dissecting the nuclear pore-like permeability barrier function of phase separated liquid FG nucleoporin condensates
剖析相分离液体 FG 核孔蛋白凝聚物的核孔样渗透屏障功能
  • 批准号:
    419070619
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes

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