術中術後の心房心室除細動用およびペーシング用ミニパドルの開発

开发用于术中和术后房室除颤和起搏的迷你桨

• 批准号: 11770734
• 负责人: 窪田 博
• 金额: $ 1.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11770734/
• 关键词: 心房細動; 心室細動; 低侵襲手術; 除細動; ペーシング; 心房ペーシング; 心室ペーシング; atrial fibrillation; atrial defibrillation; Ventricular fibrillation; Ventricular defibrillation; atrial pacing; ventricular pacing.; pace maker; defibrillator

我々は、2000年度において、一昨年度までの実験結果を踏まえ、さらにmini-paddleの性質を表す基礎データをそろえるべく実験を重ね、あるいは新たな実験項目を加えることにより臨床応用により近づく結果を得ることができた。1雑種成犬を用いた除細動閾値の測定:雑種成犬(n=7)を用いて心房除細動閾値を測定した。胸骨正中切開した後両側迷走神経を露出。刺激用電極を逢着した後心嚢切開。心房刺激用電極を右心耳に2本、ミニパドルをSinus Nodeを避けた右心房と左心房左心耳寄りに逢着した。パルス幅2msec,10Hz,2Vで迷走神経刺激を5分間行った後、Burst刺激で心房細動を誘発。心室同期にて各出力で除細動を試みた。心房除細動閾値は4.9±1.9Jであった。2雑種成犬(n=7)を用いて心室除細動閾値を測定した。心室にburst刺激を加え、心室細動を起こした後、mini-paddleを用いて除細動を試みた。心房除細動閾値は9.9±1.8Jであった。次いで、mini-paddleを用いた心房心室のペーシング閾値を雑種成犬を用いて測定した。3心房ペーシング閾値は6.0±1.5mAであった。4心室ペーシング閾値は7.2±1.7mAであった。5除細動による心筋組織の変化の観察により、30J X3回までは、心筋傷害が少なく許容範囲内と思われた。本実験結果を東京大学倫理委員会に提出した結果これを通過し、来年度から臨床応用に入る予定である。

For the first time in 2000, last year, the results of the previous year, the results of the previous year, and the results of the previous year, the mini-paddle information table, the number of new items, the number of new items, and the results of the previous year have been improved with the results of the recent results. More than 1 kinds of adult dogs were tested with exercise exercise test: several kinds of adult dogs (nong7) were measured with exercise-free atrium. The sternum was cut right in the middle of the sternum and the vagus was exposed. Stimulate the use of electricity to open your heart when you are in the mood. The right atrial appendage was used for atrial stimulation, and the right atrial appendage and the left atrial appendage were used for atrial stimulation. The right atrial appendage and the left atrial appendage were sent to the right atrium and the left atrial appendage. The amplitude of the vagus was 2msec10Hz and 2V, and the vagus was stimulated by Burst for 5 minutes, and then the atrium was stimulated by the vagus. At the same time, each ventricle made an effort to eliminate the exercise test. The heart rate of the atrium was 4.9 ±1.9J. More than 2 kinds of adult dogs (nasty 7) were measured by ventricular debridement. After the stimulation of ventricular burst and the onset of ventricular exercise, mini-paddle was used to remove the exercise test. The heart rate of the atrium was 9.9 ±1.8J. Secondary and mini-paddle were measured by atrial and ventricular echocardiography in adult dogs and adult dogs. (3) the atrium was abnormal (6. 0 ±1.5mA). (4) the heart rate of the ventricle was slightly higher than that of the control group. (4) the heart rate of the ventricle was 7.2 ±1.7mA. (5) in addition to the activity, the organization, the monitoring system, the 30J X3 feedback system, and the content range of the system. According to the results of this study, the committee of the committee of science and technology of Beijing University has proposed that the results of the election will be approved and will be used in the coming year.

项目成果

KubotaH,TakamotoS,FuruseA,KotsukaU.: "A New,Biological Glue-Mdded MINI-PADDLE Electrode Used for Afrial Pacini and Defibrillotion"Pacingand Clinial Electrophysio Logy. vol.22.No6. A184 (1999)

KubotaH、TakamotoS、FuruseA、KotsukaU.：“一种用于 Afrial Pacini 和除颤的新型生物胶微型桨电极”起搏和临床电生理学。