Long-term course of Ambulatory Assessment (AA-) phenotypes and ecological validation of cognitive processes in patients with recurrent depression

复发性抑郁症患者的动态评估（AA-）表型的长期过程和认知过程的生态验证

• 批准号: 424724133
• 负责人: Professorin Dr. Christine Kühner
• 金额: --
• 依托单位: Arbeitsbereich Pädagogische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/424724133?language=en
• 关键词: Long; term; course; Ambulatory; Assessment

The combination of intensive repeated assessments of daily life experiences at the micro-level (bursts) using Ambulatory Assessment (AA) and illness-related factors measured at the macro-level over longer term intervals is recently being regarded as an important innovative approach for dynamic modelling of mental disorders. In this context, however, respective measurement burst designs have not been applied to date for modelling characteristics of the course of illness in mental disorders. In the present project, such a design will be realized in the context of a five-year longitudinal follow-up burst of individuals with recurrent depressive episodes (n=60), who already underwent two AA bursts during a previous study. Thereby, the planned project aims to provide important insight into the stability and change of affective, cognitive, and psychoendocrinological states and processes at the micro-level (AA-phenotypes) and their determinants, measured on different time scales, and will analyse relationships between short- and longer term changes and individual differences therein in the course of illness. Conversely, we will also investigate the role of respective AA-phenotypes as predictors of the clinical course of illness at the macro-level (substudy 1).Furthermore, the interplay of mental and physiological processes during daily life with executive cognitive control and with spontaneous thought during the resting state, both assessed during standardized lab sessions, are increasingly gaining importance in the study of mental disorders. The present project aims to investigate associations of dimensions a) of executive control processes (updating, inhibiting, shifting), and b) of spontaneous thought during the resting state, assessed in the lab, with momentary cognitive (mind wandering, rumination), affective, and psychoendocrinological (cortisol output) processes during daily life in patients with recurrent depression (n=60) and healthy controls (n=60). Finally, we aim at identifying specific cognitive mediation pathways (momentary cognitive processes) contributing to the explanation of the association between dimensions of executive control and spontaneous thought in the lab with daily life mood and cortisol output (substudy 2). The two substudies are interlinked by burst 3 for substudy 1.

使用动态评估（AA）在微观层面上对日常生活经历进行密集的重复评估与在宏观层面上以较长时间间隔测量的疾病相关因素相结合，最近被视为精神障碍动态建模的重要创新方法。然而，在这种情况下，迄今为止尚未应用相应的测量突发设计来模拟精神障碍的病程特征。在本项目中，这样的设计将实现在一个五年的纵向随访突发的个人复发性抑郁发作（n=60），谁已经经历了两个AA突发在以前的研究。因此，计划中的项目旨在提供重要的洞察力的稳定性和变化的情感，认知和心理内分泌状态和过程在微观层面（AA-表型）及其决定因素，在不同的时间尺度上测量，并将分析短期和长期变化之间的关系和疾病过程中的个体差异。相反，我们也将调查各自的AA-表型的作用，在宏观层面上的疾病的临床进程的预测（子研究1）。此外，在日常生活中的心理和生理过程的相互作用与执行认知控制和自发的思考在休息状态下，在标准化的实验室会议期间进行评估，在精神障碍的研究越来越重要。本项目旨在研究复发性抑郁症患者（n=60）和健康对照组（n= 60）在日常生活中的瞬时认知（走神、沉思）、情感和心理内分泌（皮质醇输出）过程与实验室评估的静息状态下执行控制过程（更新、抑制、转移）和自发思维（B）维度之间的关联。最后，我们的目标是确定特定的认知中介途径（瞬时认知过程），有助于解释执行控制和自发思维的维度之间的关联，在实验室中与日常生活情绪和皮质醇输出（子研究2）。这两个子研究通过子研究1的突发3相互关联。