高齢者地域住民における咀嚼機能と消化管ホルモンのグレリンとの関係

社区老年居民咀嚼功能与胃肠激素ghrelin的关系

• 批准号: 17659663
• 负责人: 高田 豊
• 金额: $ 2.18万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17659663/
• 关键词: 歯学; 老化; 栄養学; 咀嚼; 消化管ホルモン; 高齢者; 歯科; 住民; 疫学調査; 口腔; グレリン

平成18年度実績報告書で行った福岡県民60・65歳393名を対象とした解析では、グレリン、レプチンと健全歯数、未処置歯数、喪失歯数、残存歯数、咀嚼食品数の間に有意の関係を認めなかった。平成19年度はこの393名に260名の高齢者を対象に加えて総数653名とし、グレリンとレプチンを測定した617名について上記の口腔指標の他に歯肉ポケット深さ(PD)、アタッチメントロス(AL)、出血個数(Bo)との関係も解析した。グレリンと健全歯数、未処置歯数、喪失歯数、残存歯数、咀嚼食品数の間に単回帰で有意な関係を認めなかったが、PD最大値(r=-0.115、P=0.005)、PD平均値(r=-0.082、P=0.043)、AL最大値(r=-0.120、P=0.003)、AL平均値(r=-0.218、P=0.000)、Bo平均個数(r=-0.088、P=0.029)との間に有意な負の関係を認めた。レプチンは健全歯数(r=-0.081、P=0.045)、残存歯数(r=-0.118、P=0.003)、残存根除去歯数(r=-0.107、P=0.008)と負の関係、PD最大値(r=0.107、P=0.008)、PD平均値(r=0.097、P=0.016)、AL平均値(r=0.171、P=0、000)と正の関係を認めた。また、年齢との間にグレリン(r=-0.377、P=0.000)は負の、レプチンは(r=0.419、P=0.000)正の関係があった。グレリン(男159.3±165.2女201.1±168.8、P=0.002)、レプチン(男16.9±25.4女33.4±54.2、P=0.000)に男女差を認めた。しかし、年齢と性差で補正をした重回帰分析においては、グレリンとPD最大値、PD平均値、AL最大値、AL平均値、Bo個数の間に有意の関係はなく、レプチンと健全歯数、残存歯数、残存根除去歯数、PD最大値、PD平均値、AL平均値の間にも有意の関係は認められなかった。以上から、単回帰で認められた有意の関係は年齢と性差を介したものであったと考えられる。

The report on the results of the year 2018 shows that the population of Fukuoka Prefecture is 60, 65 years old and 393. The analysis shows that there is a significant relationship between the number of healthy teeth, the number of untreated teeth, the number of lost teeth, the number of remaining teeth, and the number of chewing foods. In 2019, 260 out of 393 patients with high blood pressure were enrolled in the study. The total number of patients was 653. The number of patients with high blood pressure was 617. The relationship between the number of patients with high blood pressure (PD), the number of patients with high blood pressure (AL) and the number of patients with bleeding (Bo) was analyzed. The relationship between the number of healthy teeth, the number of untreated teeth, the number of lost teeth, the number of remaining teeth, and the number of chewing foods is intentional.(r=-0.115, P =0.005), PD mean value (r=-0.082, P =0.043), AL maximum value (r=-0.120, P =0.003), AL mean value (r=-0.218, P =0.000), Bo mean number (r=-0.088, P =0.029) and so on. There was a negative correlation between the number of healthy teeth (r=-0.081, P =0.045), the number of residual teeth (r=-0.118, P =0.003), the number of residual eradicated teeth (r=-0.107, P =0.008), the maximum PD value (r=0.107, P= 0.008), the mean PD value (r=0.097, P=0.016), and the mean AL value (r=0.171, P= 0.000). A negative correlation (r=-0.377, P =0.000) was found between the two groups. A positive correlation (r=0.419, P=0.000) was found between the two groups. There was a significant difference between male and female (M 159.3±165.2, F 201.1±168.8, P=0.002) and female (M 16.9±25.4, F 33.4±54.2, P=0.000). The relationship between PD maximum value, PD average value, AL maximum value, AL average value, Bo number and the relationship between PD maximum value, PD average value, AL maximum value, PD average value, PD maximum value, PD maximum value, AL average value and Bo maximum value are analyzed. The above is the first time that the relationship between the two countries has been established.

项目成果

Evaluation of the relationship between peripheral lesions /sclerotic bone and general bone density as a possible gauge of general health among 80-year olds.

评估外周病变/硬化骨与一般骨密度之间的关系，作为 80 岁老年人总体健康状况的可能衡量标准。

• 发表时间: 2005
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99(3)
• 作者: Ohba T;Takata Y;et al.
• 通讯作者: et al.

Relationship between chewing ability and 4-year mortality in a cohort of 80-year-old Japanese people

• DOI: 10.1111/j.1601-0825.2006.01269.x
• 发表时间: 2007-03-01
• 期刊: ORAL DISEASES
• 影响因子: 3.8
• 作者: Ansai, T.;Takata, Y.;Takehara, T.
• 通讯作者: Takehara, T.

Clinical significance and variation of the advanced calcified stylohyoid complex detected by panoramic radiographs among 80-year-old subjects

80岁老年人全景片检出晚期茎突舌骨复合体钙化的临床意义及变化

• 发表时间: 2006
• 期刊: Dentomaxillofac Radiol 35
• 作者: Ebisu S;et. al.;Ogawa H et al.;Okabe S et al.
• 通讯作者: Okabe S et al.

Association Between Body Mass Index and Mortality in an 80‐Year‐Old Population

• DOI: 10.1111/j.1532-5415.2007.01170.x
• 发表时间: 2007-06
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Y. Takata;T. Ansai;I. Soh;S. Akifusa;K. Sonoki;K. Fujisawa;S. Awano;S. Kagiyama;T. Hamasaki;Ikuo Nakamichi;A. Yoshida;T. Takehara

Physical fitness and 4-year mortality in an 80-year-old population

• DOI: 10.1093/gerona/62.8.851
• 发表时间: 2007-08-01
• 期刊: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
• 影响因子: 5.1
• 作者: Takata, Yutaka;Ansai, Toshihiro;Takehara, Tadamichi
• 通讯作者: Takehara, Tadamichi