On a Circulation System Monitor of HD Patient to Realize a Safe High Efficiency Dialysis (1992)

浅谈HD患者循环系统监测以实现安全高效透析（1992）

• 批准号: 02452176
• 负责人: OHTA Michio
• 金额: $ 4.1万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02452176/
• 关键词: Hemodialysys; Patients Monitor; Pressure Drop; High Efficiency; Hematocrit; Blood Volume; Blood Pressure; Continuous Measurement; 無侵襲連続計測; レ-ザ-; ヘマトクリット計測; 血液量; 酵素飽和度; 連続計測

To realize a safe but high efficiency hemodialysis, it is inevitable to know the patient state to avoid pressure drops due to the rapid water removal. Mainly two monitor systems were developed in this research projects. One is a continuous blood volume and. oxigen saturation monitor which measures continuously. For this sistem a couple of laser photodetecting circuit including the beams of 756 and 805 nn. 805 nm beam is known to be insensitive to oxigen saturation degree of hemoglobin, which in tern measures the so called heamatocrit. From the heamatocrit relative blood volume shall be calculated continuously. 756 beam is sensitive to the oxigen saturation so as to measure the saturation degree with the conbination of of 805 beam data.Continuous measurement of blood pressure is the other of urgent problem whi we encountered in this research, because of sudden pressure drops in hemodialysis patients. Based on analysis with an electric equivalent circuit of blood circulation system, a new approach has been developed here. The result of analysis gave a simple relation between pressure measured at dialysis circuit and the brachial pressure. To put this result into a clinical use, a new dialysis circuit vas designed, which include an additional air-trap.The clinical test were fairly acceptable in usefulness and noninvasive.

为了实现安全高效的血液透析，必须了解患者的状态，以避免因快速去除水分而造成压力下降。本研究项目主要开发了两种监控系统。一是连续血量和。连续测量的血氧饱和度监测仪。对于该系统，有几个激光光电检测电路，包括 756 和 805 nn 光束。众所周知，805 nm 光束对血红蛋白的氧饱和度不敏感，血红蛋白的氧饱和度通常用于测量所谓的血细胞比容。应根据血细胞比容连续计算相对血容量。 756光束对血氧饱和度敏感，可以结合805光束数据来测量饱和度。由于血液透析患者的血压突然下降，持续测量血压是我们在本研究中遇到的另一个紧迫问题。基于对血液循环系统的电气等效电路的分析，这里开发了一种新方法。分析结果给出了透析回路测得的压力与肱动脉压力之间的简单关系。为了将这一结果应用于临床，设计了一种新的透析回路血管，其中包括一个额外的空气阱。临床测试在实用性和非侵入性方面相当可接受。

项目成果

Y.SANKAI: "Artificial Kidney Control System Based on Cybernics Conception" Artificial Organs. 14(3). 291-295 (1990)

Y.SANKAI：“基于控制学概念的人工肾脏控制系统”人工器官。

太田 道男: "人工腎臓における"ながれ"の諸問題" ながれ. 11ー1. 3-13 (1992)

Michio Ota：“人工肾‘流动’的问题”Nagare 11-1 (1992)。

Y.SANKAI: "Therapeutic Robot System aimed at Human Oriented System" Proc.of IEEE International Workshop on Intelligent Motion Control. 1. 247-251 (1990)

Y.SANKAI：“面向人类的治疗机器人系统”Proc.of IEEE 国际智能运动控制研讨会。

Y. SANKAI: "Therapeutic Robot System aimed at Human Oriented System" Proc. of IEEE International Workshop on Intelligent Motion controlProc. IEEE International Workshop on Intelligent Motion Control. 1. 247-251 (1990)

Y. SANKAI：“针对以人为本的系统的治疗机器人系统”Proc。

Y. Sankai: "Continuous Measurement of Shant Blood Pressure during Hemodialysis" J. Japanese Soc. for Dialysis Therapy. 24-3. 327/331 (1991)

Y. Sankai：“血液透析期间连续测量 Shant 血压”J. Japanese Soc。