DEVELOPMENT OF INTRACRANIAL PRESSURE CONTROL SYSTEM

颅内压控制系统的研制

• 批准号: 60550286
• 负责人: OHTA Michio
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF TSUKUBA
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60550286/
• 关键词: Intracranial pressure; Optimal control; Parameter identification; ICP increasing factor; 亢進因子; グリセロール

(1) Construction of Mathematical model analysisIt is necessary to analyse various parameters responding to hypertonic solutions such as mannitol or glycerol, in order to achieve the best therapeutic results for patients having increased intraclanial pressure (ICP). The responding model system for the ICP composing of multi-compartments of blood and brain tissue was mathematically introdused.(2) Introduction of ICP increasing factorBy analysing the change of the ICP under administration of glycerol used in this system, the mathematical model for brain edema was developed. The cause of water transfer in this model system was indicated as the difference of the osmotic pressure and determined as ICP incerasing factor, V.(3) Simulation of clinical caseIt was demonstrated that this theoritical model responded quite similarly to human ICP monitored by simulating this system for clinical cases.(4) Development and Application of ICP controllerThe ICP controller was further developed. The automatic control of ICP was clinically achieved by using this controller. The minimal effective dose of glycerol can be automatically administered by presetting a desirable ICP for each patient.

(1)建立数学模型分析甘露醇或甘油等高渗液的各项参数，以达到治疗颅内压升高的最佳效果。从数学上介绍了由血和脑组织多个隔室组成的颅内压响应模型系统。(2)介绍了颅内压升高因子。通过分析该系统中所用甘油对颅内压的影响，建立了脑水肿的数学模型。通过对临床病例的模拟，证明了该理论模型与人体颅内压监测系统的反应非常相似。(4)颅内压控制器的研制与应用。该控制器在临床上实现了对颅内压的自动控制。通过为每个患者预先设置理想的颅内压，可以自动给药甘油的最小有效剂量。

项目成果

Y. KUMAGAI: "Intraclanial Pressure Monitoring by Hydrostatic Pressure Balance Method" Neurologia medico-chirurgica. 25. 826-831 (1985)

Y. KUMAGAI：“通过静水压力平衡法监测颅内压”Neurologia medico-chirurgica。

熊谷頼佳: Neurologia medico-chirurgica. 25. 826-831 (1985)

Yorika Kumagai：神经外科医学 25. 826-831 (1985)