DEVELOPMENT OF INTRACRANIAL PRESSURE CONTROL SYSTEM

颅内压控制系统的研制

• 批准号: 60550286
• 负责人: OHTA Michio
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF TSUKUBA
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60550286/
• 关键词: Intracranial pressure; Optimal control; Parameter identification; ICP increasing factor; 亢進因子; グリセロール

(1) Construction of Mathematical model analysisIt is necessary to analyse various parameters responding to hypertonic solutions such as mannitol or glycerol, in order to achieve the best therapeutic results for patients having increased intraclanial pressure (ICP). The responding model system for the ICP composing of multi-compartments of blood and brain tissue was mathematically introdused.(2) Introduction of ICP increasing factorBy analysing the change of the ICP under administration of glycerol used in this system, the mathematical model for brain edema was developed. The cause of water transfer in this model system was indicated as the difference of the osmotic pressure and determined as ICP incerasing factor, V.(3) Simulation of clinical caseIt was demonstrated that this theoritical model responded quite similarly to human ICP monitored by simulating this system for clinical cases.(4) Development and Application of ICP controllerThe ICP controller was further developed. The automatic control of ICP was clinically achieved by using this controller. The minimal effective dose of glycerol can be automatically administered by presetting a desirable ICP for each patient.

(1)数学模型分析的构建为了使颅内压(ICP)增高的患者获得最佳的治疗效果，需要分析甘露醇或甘油等高渗溶液的各种参数的响应。数学上介绍了由血液和脑组织组成的多室ICP响应模型系统。(2)ICP增加因子的引入通过分析该系统中使用的甘油给药后ICP的变化，建立了脑水肿的数学模型。该模型系统中水转移的原因被表示为渗透压的差异，并被确定为ICP增加因子V。(3)临床病例的模拟通过模拟该系统的临床病例，证明该理论模型与人体ICP监测的响应非常相似。(4)ICP控制器的开发和应用进一步开发了ICP控制器。利用该控制器在临床上实现了ICP的自动控制。通过为每位患者预设所需的 ICP，可以自动施用最小有效剂量的甘油。

项目成果

Y. KUMAGAI: "Intraclanial Pressure Monitoring by Hydrostatic Pressure Balance Method" Neurologia medico-chirurgica. 25. 826-831 (1985)

Y. KUMAGAI：“通过静水压力平衡法监测颅内压”Neurologia medico-chirurgica。

熊谷頼佳: Neurologia medico-chirurgica. 25. 826-831 (1985)

Yorika Kumagai：神经外科医学 25. 826-831 (1985)