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Measurement of Local Micro-Electroretinogram and Sequential Data Analysis

局部微视网膜电图测量和序列数据分析

基本信息

批准号：
02452181
负责人：
MORITA Tatsuya
金额：
$ 3.78万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

Electroretinogram(ERG) gives diagnostic information in the clinical ophthalomogy. However, the partial activities of the retina cannot be revealed, because of the whole area stimulation by powerful flush light.In this study, a new method using photodiode(LED) stimulation was proposed for analyzing the frequency characteristics of the local micro-ERG. Advantage of this method was applicability of linear system analysis to the mu ERG evoked by partial stimulation of computer controlled wave form.In 1990, two basic techniques, Fourier analysis of synchronous ERG to the sinusoidal stimulation and correlation analysis using random stimulation were compared. It was concluded that correlation analysis was more effectively to simplify the experimental procedure.In 1991, mu ERG evoked along the horizontal axis of the retina by random signal stimulation of red and orange LED was analyzed by wellknown correlation technique. Also, component analysis on the mu ERG was achieved applying the least square error estimation method to a mu ERG model consisted of five 2nd order transfer functions. It was concluded in the analysis that mu ERG consisted of similar component waves of the flush ERG. That is, the flush ERG corresponded to the spatial summation of mu ERG over whole retina.In 1992, interaction between mu ERGs evoked from two parts of the retina was analyzed. Two LEDs were used to stimulate the retina. The central and peripheral parts were stimulated at first time individually,and then simultaneously. The experimental results were analyzed on the assumption that the response to simultaneous stimulation was composed by the same components as those of the individual response. It was concluded from the analysis using least square error method that mu ERGs inhibitorily interacted within negligible silent period.

视网膜电图（ERG）提供临床眼科诊断信息。然而，由于强冲洗光对整个区域进行刺激，因此无法显示视网膜的部分活动。在本研究中，提出了一种利用光电二极管（LED）刺激来分析局部微ERG频率特性的新方法。该方法的优点是线性系统分析适用于由计算机控制波形的部分刺激引起的μ ERG。1990年，比较了两种基本技术：同步ERG对正弦刺激的傅立叶分析和使用随机刺激的相关分析。结论是相关分析能更有效地简化实验过程。1991年,利用众所周知的相关技术对红色和橙色LED随机信号刺激沿视网膜水平轴诱发的μ ERG进行了分析。此外，对由五个二阶传递函数组成的 mu ERG 模型应用最小二乘误差估计方法，实现了 mu ERG 的成分分析。分析得出结论，μ ERG 由与冲洗 ERG 类似的分量波组成。也就是说，flush ERG 对应于整个视网膜上 mu ERG 的空间总和。 1992 年，分析了视网膜两部分引起的 mu ERG 之间的相互作用。使用两个 LED 来刺激视网膜。先分别刺激中枢部和末梢部，然后同时刺激。实验结果的分析假设是对同时刺激的反应由与个体反应相同的成分组成。使用最小二乘误差法分析得出结论，μ ERGs 在可忽略的沉默期内抑制性相互作用。