RESEARCH FOR THE MECHANISM OF MUCIN SECRETORY EFFECTS BY DIETARY FIBER AND ITS PHYSIOLOGICAL SIGNIFICANCE

膳食纤维粘蛋白分泌作用的机制及其生理意义研究

• 批准号: 21580136
• 负责人: MORITA Tatsuya
• 金额: $ 3.16万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580136/
• 关键词: 栄養化学; 食物繊維; ムチン; 粘度; 嵩; 杯細胞; アレルギー

Mucin is a key component of the gut barrier that prevents potential pathogens and antigens from gaining access to the underlying epithelium. The study examined physicochemical properties of dietary fiber(DF) that determine small intestinal mucin secretion. It turned out that small intestinal mucins were secreted in proportion to the settling volume in water(bulk-forming properties) of water-insoluble DF or the viscosity of water-soluble DF. The stimulatory effects of both soluble and insoluble DF on mucin secretion appear to be linked to the subsequent increase in goblet cell number.

粘蛋白是肠道屏障的关键组成部分，其防止潜在的病原体和抗原进入下层上皮。该研究检查了决定小肠粘蛋白分泌的膳食纤维（DF）的理化性质。结果表明，小肠粘蛋白的分泌与水不溶性DF在水中的沉降体积（体积形成特性）或水溶性DF的粘度成比例。可溶性和不溶性DF对粘蛋白分泌的刺激作用似乎与随后杯状细胞数量的增加有关。

项目成果

Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats

短链菊粉类果聚糖对三硝基苯磺酸诱导的大鼠结肠炎愈合阶段的改善作用

• DOI: 10.1271/bbb.110460
• 发表时间: 2011
• 期刊: Bioscience, Biotechnology, and Biochemistry
• 作者: Shingo Hino;Hiroyuki Ito;Hiroyuki Bito;Hirokazu Kawagishi;Tatsuya Morita
• 通讯作者: Tatsuya Morita

Soluble Fiber Viscosity Affects Both Goblet Cell Number and Small Intestine Mucin Secretion in Rats

• DOI: 10.3945/jn.109.110171
• 发表时间: 2009-09-01
• 期刊: JOURNAL OF NUTRITION
• 影响因子: 4.2
• 作者: Ito, Hiroyuki;Satsukawa, Mitsuru;Morita, Tatsuya
• 通讯作者: Morita, Tatsuya

高体積・高粘度食物繊維の摂取による小腸杯細胞応答は期間非依存的なシアロムチン分泌型の 増加による

由于摄入大量、高粘度膳食纤维而引起的小肠杯状细胞反应是由于唾液酸粘蛋白分泌类型的时间依赖性增加所致。

• 作者: 福田 智紀;河田 伊織;伊藤 弘幸;日野 真吾;森田 達也
• 通讯作者: 森田 達也

Toxic isolectins from the mushroom Boletus venenatus

• DOI: 10.1016/j.phytochem.2009.12.003
• 发表时间: 2010-04-01
• 期刊: PHYTOCHEMISTRY
• 影响因子: 3.8
• 作者: Horibe, Masashi;Kobayashi, Yuka;Kawagishi, Hirokazu
• 通讯作者: Kawagishi, Hirokazu

Short-chain inulin-like fructans reduce endotoxin and bacterial translocations and attenuate the development of TNBS-induced colitis in rats

短链菊粉样果聚糖可减少内毒素和细菌易位，并减轻 TNBS 诱导的大鼠结肠炎的发展

• 发表时间: 2009
• 期刊: Digestive Diseases and Sciences 54
• 作者: 伊藤弘幸;加藤俊彦;河田伊織;森田達也;桐山修八;伊藤弘幸
• 通讯作者: 伊藤弘幸