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RESEARCH FOR THE MECHANISM OF MUCIN SECRETORY EFFECTS BY DIETARY FIBER AND ITS PHYSIOLOGICAL SIGNIFICANCE

RESEARCH FOR THE MECHANISM OF MUCIN SECRETORY EFFECTS BY DIETARY FIBER AND ITS PHYSIOLOGICAL SIGNIFICANCE
膳食纤维粘蛋白分泌作用的机制及其生理意义研究
批准号:
21580136
负责人:
MORITA Tatsuya
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Mucin is a key component of the gut barrier that prevents potential pathogens and antigens from gaining access to the underlying epithelium. The study examined physicochemical properties of dietary fiber(DF) that determine small intestinal mucin secretion. It turned out that small intestinal mucins were secreted in proportion to the settling volume in water(bulk-forming properties) of water-insoluble DF or the viscosity of water-soluble DF. The stimulatory effects of both soluble and insoluble DF on mucin secretion appear to be linked to the subsequent increase in goblet cell number.
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Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats
短链菊粉类果聚糖对三硝基苯磺酸诱导的大鼠结肠炎愈合阶段的改善作用
DOI: 10.1271/bbb.110460
发表时间: 2011
期刊: Bioscience, Biotechnology, and Biochemistry
影响因子: --
作者: [Shingo Hino, Hiroyuki Ito, Hiroyuki Bito, Hirokazu Kawagishi, Tatsuya Morita]
通讯作者: Tatsuya Morita
DOI: 10.3945/jn.109.110171
发表时间: 2009-09-01
期刊: JOURNAL OF NUTRITION
影响因子: 4.2
作者: [Ito, Hiroyuki, Satsukawa, Mitsuru, Morita, Tatsuya]
通讯作者: Morita, Tatsuya
高体積・高粘度食物繊維の摂取による小腸杯細胞応答は期間非依存的なシアロムチン分泌型の 増加による
由于摄入大量、高粘度膳食纤维而引起的小肠杯状细胞反应是由于唾液酸粘蛋白分泌类型的时间依赖性增加所致。
DOI: --
发表时间:
期刊:
影响因子: --
作者: [福田 智紀, 河田 伊織, 伊藤 弘幸, 日野 真吾, 森田 達也]
通讯作者: 森田 達也
DOI: 10.1016/j.phytochem.2009.12.003
发表时间: 2010-04-01
期刊: PHYTOCHEMISTRY
影响因子: 3.8
作者: [Horibe, Masashi, Kobayashi, Yuka, Kawagishi, Hirokazu]
通讯作者: Kawagishi, Hirokazu
23
    Elucidation of the mutualistic relationship between host and gut microbiota mediated by mucin and its application
    • 批准号:
      20H02929
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2020
    • 负责人:
      MORITA Tatsuya
    • 依托单位:
    Mixed-methods study of a rehabilitation program for advanced cancer patients.
    • 批准号:
      26350595
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      MORITA Tatsuya
    • 依托单位:
    Potential of immune modulatory effect of dietary fiber through goblet cell proliferation
    • 批准号:
      25660101
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      MORITA Tatsuya
    • 依托单位:
    Research on the mechanism of stimulated mucin secrefion by dietary fiber ingestion and its physiological effects
    • 批准号:
      18580116
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2006
    • 负责人:
      MORITA Tatsuya
    • 依托单位:
    海外基金