Laser photocoagulation treatment for choroidal neovascularization, experimental study

老年性黄斑变性是老年人失明的主要原因。这种疾病源于脉络膜新生血管（ChNV），激光光凝（PC）仅是一种可预期的治疗方法。我们用氪激光PC在猴视网膜上实验性地产生了ChNV。在激光中，氩激光和染料激光（波长为577、590、830 nm）以弱或强PC应用于ChNV网，其通过荧光素血管造影显示。PC术后3个月进行临床及组织病理检查，PC较弱或不足者，视网膜下腔内残留新生血管，病变未愈合。重度或完全性PC时，ChNV在病灶处消失，病灶形成瘢痕愈合。氩激光PC不足，损坏了内层视网膜。577和590 nm的染料激光对ChNV的封闭最有效。这些结果表明，虹膜光凝治疗脉络膜新生血管，577和590 nm的染料激光是最有效的，强烈和完全的凝固覆盖整个区域的新生血管膜是必要的，以封闭视网膜下的新血管。这些结果为临床提供了有意义的信息。

Senile disciform macular degeneration is now a leading cause of blindness in the elderly people. The disease arises from choroidal neovascularization (ChNV), for which laser photocoagulation (PC) is only a expectable treatment. We produced ChNV experimentally in the monkey retinas with krypton laser PC. Laser PC treatments were attempted for these experimentally produced ChNV in the monkey eyes, to determine the most effective reannual in laser PC treatment.Among lasers, argon laser, and dye laser (wavelengths of 577, 590, 830 nm) were applied with weak or intense PC for ChNV nets which were revealed with fluorescein angiography. After PC, fundi were checked clinically and histapathologically for 3 months.With weak or insufficient PC, newly formed vessele had remained in the subretinal space and the lesion did not healed. With intense or complete PC, ChNV were obliterated and disappeared at the lesion, and the lesion become scarring to heal. Argon laser PC was insufficient and damaged to the inner retina. Dye lasers of 577 and 590 nm were most effective to occlude ChNV.These results showed that Iriser photocoagulation treatment for choroidal neovascularization, dye laser of 577 and 590 nm are most effective, and intense and complete coagulation covering the entire area of neovascular membrane is necessary to occlude the new vessel beneath the retina. These results indicate a significant information in clinical reannual.