A Development of Non-releasing Antibacterial Composite Resin.

非释放抗菌复合树脂的研制。

基本信息

批准号：
02454436
负责人：
TORII Mitsuo
金额：
$ 3.9万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

In order to give composite resin enduring antibacterial activity without a fall of mechanical properties, we attempted to develop the non-rele asing antibacterial composite resin. An antibacterial monomer, which is the combination of antibacterial agent and polymerizable group, is expected to bind chemically to base resin of composite resin and give the non-releasing antibacterial activity.Two kinds of antibacterial monomer were synthesized by combining antibacterial agent and methacryl group without decrease of antibacterial activity. One is 2methacryloyloxyethyl-p-hydroxy benzoate (MBA) and another is 12methacryloyloxydodecylpyridinium bromide (MDPB). When these two antibacterial monomers were added in composite resin. -the resin showed non-releasing antibacterial activity, that is, the resin released very few antibacterial agent which was far less than its MIC, however, killed bacteria which touched the surface of the resin.The antibacterial activity of MBA was low and it was necess … More ary to add MBA more than 1 % (wt/wt) (final concentration) of composite resin to get sufficient antibacterial activity. At such a high concentration, unnegligible amount of MBA remained unpolymerized and it was released from composite resin. We decided that MBA was of no practical use.MDPB possessed pretty strong antibacterial activity and the composite resin containing 0.1 - 0.2 % (wt/wt) (final concentration) MDPB showed clear antibacterial activity. The composite resin containing 0.1 % MDPB did not release detectable amount of MDPB (detection limit : 1 ug/ml) when it was immersed in either water, ethanol or n-heptan for six months. The composite resin containing 0.2 % MDPB also did not release MDPB when it was immersed in water or n-heptan, but 1.17 ug/ml of MDPB was released in ethanol after five months. We think this degree of release is practically negligible. The MDPB containing composite resin gathered clearly less amount of artificial plaque compared to control resin. Both antibacterial and anti-plaque activity of MDPB containing composite resin did not change after three-month immersinon in water. There was no significant difference between the mechanical properties of the resin and those of control resin after three months immersion in water.As shown above, composite resin was given non-releasing antibacterial activity by adding MDPB. Less

为了提供复合树脂持久的抗菌活性而没有机械性能的落下，我们试图开发非释放抗菌复合树脂。一种抗菌单体是抗菌剂和可聚合基团的组合，预计将化学与复合树脂的基础树脂结合，并给出非释放抗菌活性的非释放抗菌活性。两种抗菌单体的种类是通过结合抗细菌剂和抗甲基丙烯酰基的替代活性而合成的抗菌单体。一种是2methacryloyloyloyloxythyl-p-羟基苯甲酸酯（MBA），另一个是12methacryloyloyloyloyloyloydodecylpyridinium bromide（MDPB）。当在复合树脂中添加这两个抗菌单体时。 -the resin showed non-releasing antibacterial activity, that is, the resin released very few antibacterial agent which was far less than its MIC, however, killed bacteria which touched the surface of the resin.The antibacterial activity of MBA was low and it was necessary … More ary to add MBA more than 1 % (wt/wt) (final concentration) of composite resin to get sufficient antibacterial activity.在如此高的浓度下，不可忽略的MBA量保持不交流，并从复合树脂中释放出来。我们认为MBA没有实际用途。MDPB具有非常强大的抗菌活性，并且复合树脂含有0.1-0.2％（wt/wt）（终浓度）MDPB显示出明显的抗菌活性。含有0.1％MDPB的复合树脂在将其浸入水，乙醇或N-Heptan中六个月时，未释放可检测量的MDPB（检测极限：1 ug/ml）。含有0.2％MDPB的复合树脂在浸入水或N- heptan中时也没有释放MDPB，但是五个月后在乙醇中释放了1.17 ug/ml的MDPB。我们认为这种释放程度实际上可以忽略不计。与对照树脂相比，含有复合树脂的MDPB显然收集的人造牌匾量较少。三个月浸入水中后，含有复合树脂的MDPB的抗菌和抗斑块活性都不会改变。浸入水中三个月后，树脂的机械性能与对照树脂的机械性能之间没有显着差异。如上所述，通过添加MDPB，对复合树脂的抗菌活性进行了非释放抗菌活性。较少的