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A Biochemical Study on the Growth Pathogenic Factor and Inhibitory Mechanism of Jaw Cysts

A Biochemical Study on the Growth Pathogenic Factor and Inhibitory Mechanism of Jaw Cysts
颌骨囊肿生长致病因子及抑制机制的生化研究
批准号:
02454453
负责人:
SUZUKI Mitsugu
金额:
$3.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1990
资助国家:
日本
项目状态:
已结题
起止时间:
1990 至 1991

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中文摘要
翻译
它被认为是通过内部流体压力的进程进行的cyst cavity的加速,或者在cyst wall组织中产生的PGE_2。不管怎样,它是一个独立于细胞扩增机制的人。因此,在本研究中,有63个案例,有各种感染过程都被选定,从细菌学试验、血液细胞定例、气体部分压力在细胞流动和微循环中被研究出血液流动中的血液流动价值比率,在细胞流动到另一侧相同的地方。在细菌的可疑性测试中,感染从非线性山梨糖基^* 或含有20%葡萄糖溶液的抗生素3+中治愈,这是一个星期。量化了cyst fluids和cyst wall因素的价值,以及在触发之后的变化。PCOH的价值,即经过制备的LPO指数与CL-HPLC和LOO基础设施与ESR进行了测量。甲氧酸代谢物已被用PG-HPL测定 ... More C测量系统。骨骼矿物成分被FT/IR调查。结果表明,感染细胞流体显示出荧光素数量较高,Hb值较高, Fe^<2+>集中,pO_2值较低。感染cyst fluids and wall展示了高PC-户外, LOO radicals。然而,PC-户外和LOO自由基体的价值被降解,在非感染细胞流体的触发下。较低的血流比率已经增加。TBX_4/6-Keto-PGF_<1alpha>已被淹没。PGE_2/PGF_<2alpha>was decreased。PO_4^&lt;3-&gt;在细胞周围的骨骼吸收和展示的骨骼重塑中得到了加强。因此,有人建议对Jaw cyst进行讨论,将由细胞腔中产生的自由基物结合在一起,并导致了微循环cyst wall连通性tissues的损害。this indicated that O^-_and · OH were inhibited which infection of cyst cavity produced O^-_and · OH.过度使用不合理的方法可能被控制以扩展细胞大小,这种方法清除O^-_由山梨糖基^* 和·OH由20%葡萄糖。Less(低)
英文摘要
It was suggested that the enlargement of jaw cysts grow because of the bone resorbtion by intracystic fluid pressure progression of cyst cavity, or produced of PGE_2 in the cyst wall tissue. However, it is indefiniteners as to the cyst enlargement mechanism.So in this study, 63 cases with various infection process were selected, was concended from bacteriological examination, blood cell constituent, gas partial pressure in cyst fluid and micro circulation blood flow was studied from blood flow value ratio of inferior alveolar in place of cyst to the other side same place. The infection cured from irrigational Solcoseryl^* or 20% glucose solution with containing antibiotics 3+ in susceptibility test of bacteria and it was for a week. The quantify the value of cyst fluids and cyst walls factor and after the irrigation were anlysed. Value of PCOOH for index of proucted LPO was measured with CL-HPLC and LOO radicals was measured with ESR. Arachidonic acid metabolic was measured with PG-HPL … More C measurement system. Component of bone mineral was investigated with FT/IR.The result, infection cyst fluids showed high number of lucocyitic, high value of Hb, Fe^<2+> concentration, low value of pO_2. Infection cyst fluids and walls showed high PC-OOH, LOO radicals. But there values of PC-OOH and LOO radicals were decreased, in non-infection cyst fluids by the irrigation of cyst cavity. Bloodflow ratio of inferior was increased. Cyst wall of TBX_4/6-Keto-PGF_<1alpha> was increased. PGE_2/PGF_<2alpha> was decreased. PO_4^<3-> was stronged in absorbance of bones around the cysts, and showed bone remodeling.Therefore, it is suggested that the enlargement of jaw cyst was concerned with free radicals generated by infection in the cyst cavities, and that is caused by the damage of micro circulation cyst wall connective tissues, this indicated that O^-_ and ・ OH were inhibited which infection of cyst cavity produced O^-_ and ・ OH. Moreover the irrigational method was possibility controlled to enlargment of cyst size, this scavenged O^-_ by Solcoseryl^* and ・OH by 20% glucose. Less
期刊论文(28)
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会议论文
MITSUGU SUZUKI: "A Biochemical Study on the Growth Pathogenic Factor and Inhibitory Mechanism of Jaw Cysts [II]-Investigation on Inhibitory Effect of the Growth of Cyst by Irrigation in Cyst Cavity from the Behaviour of Free Radicals and LPO of Produced i
MITSUGU SUZUKI:《颌骨囊肿生长致病因子及抑制机制的生化研究[II]——从产生的自由基和LPO行为探讨囊腔内灌水对囊肿生长的抑制作用
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鈴木 貢: "嚢胞性疾患とFree Radicalー顎嚢胞内容液のFree Redical生成とその抑制についてー" 活性酸素・フリ-ラジカル. 12. (1992)
Mitsugu Suzuki:“囊性疾病和自由基 - 颌囊肿液中游离红的产生及其抑制”活性氧和自由基 12。(1992)。
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鈴木 貢: "顎嚢胞の発症因子と抑制機序に関する臨床生化学的研究(II)ー特に、内容液と嚢胞壁に生成するフリ-ラジカルとLPOの消長からみた嚢胞腔洗浄による嚢胞増大の抑制効果の検討についてー" 炎症. 12(6). (1992)
铃木光:“颌骨囊肿的致病因素和抑制机制的临床生化研究(二)——特别是从内部液体中产生的自由基和LPO的变化角度,通过清洁囊肿腔来抑制囊肿的扩大。囊肿壁。关于影响的研究-”炎症。12(6)。(1992)
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MITSUGU SUZUKI: "A biochemical study on the nature of jaw cysts (IV)-Investigation of the growth pathogenic factor and inhibitory mechanism of jaw cysts-" Journal of Cranio-Maxillo-Facial Surgery. 20. (1992)
MITSUGU SUZUKI:“颌骨囊肿性质的生化研究(IV)-颌骨囊肿生长致病因素及其抑制机制的研究-”颅颌面外科杂志。
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共 11 条
    Development of a laboratory experiment checking achievement for engineering education with Open-Ware system design
    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 批准年份:
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