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REEVALUATION OF THE REGULATORY FUNCTION OF SATURATED FATS ON CHOLESTEROL METABOLISM;STUDIES WITH INTERESTERIFIED FATS.

重新评估饱和脂肪对胆固醇代谢的调节功能；感兴趣的脂肪的研究。

基本信息

批准号：
03453134
负责人：
SUGANO Michihiro
金额：
$ 4.29万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

Effects of dietary lauric, myristic, palmitic and stearic acids on lipid metabolism were investigated in rats and hamsters using interesterified fats. When rats were fed cholesterol-supplemented diets, these saturated fatty acids did not influence the concentration of serum lipids. However,stearic acid decreased the concentrations of hepatic cholesterol and triglyceride, whereas palmitic acid decreased hepatic triglyceride. Stearic acid again decreased the concentration of hepatic cholesterol in hamsters fed a cholesterol-supplemented diet, whereas dietary saturated fatty acids showed no effects on other lipid parameters. In hamsters fed a cholesterol-free diet, both stearic and palmitic acids decreased the concentrations of hepatic cholesterol, whereas serum cholesterol was reduced only by stearic acid. The increased fecal excretion of fatty acids and neutral steroids was observed on feeding stearic and palmitic acids in rats and hamsters. Fractional catabolic rate of low density lipoproteins (LDL) was higher only in stearic acid when hamsters were fed a high cholesterol diet, whereas it was not influenced when hamsters were fed a cholesterol-free diet. The concentration of LDL receptor protein was not altered by a series of saturated fatty acids. The extent of platelet aggregation induced by ADP and the production of aortic prostacyclin was lower in stearic acid in rats fed a cholesterol-supplemented diet. Saturated fatty acids appeared to be differently influence the metabolism of linoleic acid in liver phospholipids. These observations suggest that the different saturated fatty acids exert different effects on various lipid parameters.

使用酯交换脂肪研究了膳食月桂酸、肉豆蔻酸、棕榈酸和硬脂酸对大鼠和仓鼠脂质代谢的影响。当给大鼠喂食补充胆固醇的饮食时，这些饱和脂肪酸不会影响血清脂质浓度。然而，硬脂酸降低了肝胆固醇和甘油三酯的浓度，而棕榈酸降低了肝甘油三酯。硬脂酸再次降低了饲喂补充胆固醇饮食的仓鼠的肝脏胆固醇浓度，而饮食中的饱和脂肪酸对其他脂质参数没有影响。在喂养无胆固醇饮食的仓鼠中，硬脂酸和棕榈酸均降低了肝胆固醇的浓度，而血清胆固醇仅被硬脂酸降低。在给大鼠和仓鼠喂食硬脂酸和棕榈酸后，观察到脂肪酸和中性类固醇的粪便排泄增加。当仓鼠喂食高胆固醇饮食时，低密度脂蛋白（LDL）的分数分解代谢率仅在硬脂酸中较高，而当仓鼠喂食无胆固醇饮食时则不受影响。一系列饱和脂肪酸不会改变LDL受体蛋白的浓度。在饲喂补充胆固醇饮食的大鼠中，硬脂酸中 ADP 诱导的血小板聚集程度和主动脉前列环素的产生较低。饱和脂肪酸似乎对肝磷脂中亚油酸的代谢有不同的影响。这些观察结果表明，不同的饱和脂肪酸对各种脂质参数产生不同的影响。