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脂肪酸代謝の制御に対するセサミンと共役型多価不飽和脂肪酸の共同効果解析

芝麻素与共轭多不饱和脂肪酸调节脂肪酸代谢的联合效应分析

基本信息

批准号：
11660130
负责人：
SUGANO Michihiro
金额：
$ 2.3万
依托单位：
Prefectural University of Kumamoto
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11660130/
关键词：
CONJUGATED LINOLEIC ACID CONJUGATED LINOLENIC ACID SESAMIN WHITE ADIPOSE TISSUE BROWN ADIPOSE TISSUE LEPTIN FATTY ACID β-OXIDATION RATS AND MICE 腫瘍壊死因子α ラットセサミン(ゴマリグナン)TNF-α

项目摘要

Aiming at the synergistic effect of sesamin, a food factor that simulates fatty acid metabolism, on body fat reducing potential of conjugated linoleic acid(CLA), a series of animal experiments were carried out. To know the mechanism of action of this combination serum concertration of obesity-related cytokines and hepatic fatty acid β-oxidation activity were analyzed. In rat studies, feeding CLA and sesamin at dietary levels of 1% and 0.2%, respectively resulted in a synergism in the reduction of epididymal adipose tissue weight, and the effect was marked when the dietary protein source was soybean protein in relation to casein. The weight of brown adipose tissue increased with this combination. However, no effect was observed in concentration of serum leptin and TNF-α. When mice were fed CLA, the weight of white adipose tissues and concentration of serum cytokines reduced significantly, but there was no additional effect of sesamin in this animal model. The conjugated derivative of α-linolenic acid appeared to stimulate hepatic fatty acid oxidation more than that of CLA.In addition, CLA increased the production of immunoglobulins by splenic lymphocytes probably through the modification of polyunsaturated fatty acid metabolism.These results showed the possibility that, although the response differ among the animal species, an appropriate combination of CLA with food factors that stimulate fatty acid metabolism not only stimulates the function of CLA to reduce body fat, but also produces favorable immune situation.

为探讨模拟脂肪酸代谢的食物因子芝麻素对共轭亚油酸(CLA)降脂潜力的协同作用，进行了一系列动物实验。分析血清肥胖相关细胞因子浓度和肝脏脂肪酸β-氧化活性，以了解其作用机制。在大鼠的研究中，分别以1%和0.2%的饲料水平饲喂共轭亚油酸和芝麻素，在降低附睾脂肪组织重量方面有协同作用，当饲料蛋白质来源为大豆蛋白和酪蛋白时，效果显著。棕色脂肪组织的重量随着这种组合的增加而增加。但对血清瘦素和肿瘤坏死因子-α水平无明显影响。灌胃共轭亚油酸后，小鼠白色脂肪组织重量和血清细胞因子浓度显著降低，但芝麻素对该动物模型无额外影响。α-亚麻酸的共轭衍生物对肝脏脂肪酸氧化的刺激作用强于共轭亚油酸。此外，共轭亚油酸可能通过修饰多不饱和脂肪酸代谢而增加脾淋巴细胞免疫球蛋白的产生。这些结果表明，尽管不同动物的反应不同，但共轭亚油酸与刺激脂肪酸代谢的食物因子适当结合，不仅能刺激共轭亚油酸降低体脂的功能，还能产生良好的免疫状况。