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Multisensory integration in the nonspiking giant interneurons, with special reference to the compensatory oculomotor response

非尖峰巨型中间神经元的多感觉整合，特别是代偿性动眼神经反应

基本信息

批准号：
03454024
负责人：
YAMAGUCHI Tsuneo
金额：
$ 4.03万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

Three pairs of nonspiking giant interneurons (G1, G2, G3 ; NGIs) respond with depolarizing or hyperpolarizing graded potentials to visual stimuli (Okada and Yamaguchi, 1989). In the present experiments, we obtained the following results.The NGIs respond with depolarizing and hyperpolarizing graded potentials to body tilt in roll to the ipsi- and contralateral sides in the dark. In ipsilaterally statocystectomized animals, all the NGIs respond with hyperpolarizing potentials only to the contralateral side-down tilt, whereas in contralaterally statocystectomized animals, they respond with depolarizing potentials only to the ipsilateral side-down tilt. In bilaterally statocystectomized animals, none of the NGIs respond to body tilt in the dark, but in the presence of a overhead light, they exhibit depolarizing and hyperpolarizing potentials in response to body tilt to the ipsi- and contralateral sides, respectively. The amplitude of visual responses varies in association with the amplitude of the geotactic response produced by body tilt. On the other hand, in bilaterally statocystectomized animals the NGIs respond with depolarizing and hyperpolarizing graded potentials to upward and respond to substrate tilt about the longitudinal axis of the body in the dark. Relationships between the polarity of potential and the direction of movement in the contralateral walking legs were just opposite to those in the ipsilateral walking legs. In intact animals the NGIs hardly respond to leg movements in the dark.These results indicate that the NGIs integrate the sensory inputs from eyes, statocysts, and leg proprioceptors and that the interaction between sensory inputs from the left and right sensory organs with either the same modality or with different modalities enhance the directional sensitivity of NGIs as premotoneurons in the compensatory oculomotor system.

三对非尖峰巨型中间神经元（G1、G2、G3；NGI）以去极化或超极化分级电位对视觉刺激做出反应（Okada 和 Yamaguchi，1989）。在本实验中，我们获得了以下结果。NGI 在黑暗中以去极化和超极化分级电位响应身体向同侧和对侧滚动的倾斜。在同侧静囊切除的动物中，所有 NGI 仅对对侧侧下倾斜产生超极化电位响应，而在对侧静囊切除的动物中，它们仅对同侧侧下倾斜产生去极化电位响应。在双侧睾丸切除术的动物中，没有一个 NGI 对黑暗中的身体倾斜做出反应，但在头顶灯存在的情况下，它们分别表现出去极化和超极化电位，以响应身体向同侧和对侧的倾斜。视觉反应的幅度与身体倾斜产生的地向反应的幅度相关。另一方面，在双侧静囊切除的动物中，NGI 对向上的去极化和超极化分级电位做出反应，并对黑暗中围绕身体纵轴的基底倾斜做出反应。对侧步行腿的电位极性与运动方向的关系与同侧步行腿正好相反。在完整的动物中，NGI 在黑暗中几乎对腿部运动做出反应。这些结果表明，NGI 整合了来自眼睛、静态囊和腿部本体感受器的感觉输入，并且来自左右感觉器官的感觉输入之间的相互作用，无论是相同形式还是不同形式，都增强了 NGI 作为代偿性动眼神经系统中前运动神经元的方向敏感性。