Experimental infection and characterigation of hepatitis F

我们试图找出导致非甲、非乙、非丙、非丁、非戊型肝炎的新病毒，也就是所谓的f型肝炎。我们给4只黑猩猩接种了传染性物质。然而，我们未能在动物身上制造肝炎。我们也未能从F型肝炎患者的血清中克隆病毒基因组，但我们可以在约80%的F型肝炎患者的血清中发现HBVDNA。突变型乙型肝炎病毒基因组在x区表现出典型的突变。这些x区突变导致乙型肝炎病毒增殖减少，在患者中未发现任何HBV标记物。综上所述，我们发现所谓的F型肝炎病毒实际上是变异的B型病毒。

Attempt was made to identify new virus responsible for non-A, non-B, non-C, non-D, non-E hepatitis, so-called hepatitis F.We have inoculated infectious materials into 4 chimpanzees. However, we failed to produce hepatitis in animals. We also failed to clone virus genome from sera of the patients with hepatitis F.However, we could find HBVDNA in sera of patients with hepatitis F about 80 % of those cases. This mutant hepatitis B virus genome showed typical mutation at X-region. Those mutation of X-region resulted reduced proliferation of hepatitis B virus and we could not find any markers of HBV in patients. In summary them, we found that so-called hepatitis F virus is actually mutant B virus.