Studies on non-A, non-B hepatitis.

尽管对输血后和肠道传播两种非甲、非乙型肝炎的致病病毒已做了大量的鉴定工作，但尚无可靠的垫状病毒颗粒鉴定报告。我们的研究小组在这两年中成功地证明了非甲非乙型肝炎的病毒颗粒。首先，我们将缅甸仰光散发性非甲非乙型肝炎患者的粪便材料接种到食蟹猴身上，并从感染动物的胆汁中提取病毒颗粒。这种病毒也成功地传播给了第二代和第三代动物。对于输血后非甲、非乙型肝炎，我们在感染黑猩猩的血清中发现了病毒颗粒，经过梯度离心。病毒直径为36~64 nm，形态与TOGA病毒相似。我们现在正在尝试对这两种病毒进行分子克隆。

Although a considerable number of works had been done to identify the causative virus of two types of non-A, non-B hepatitis, that is post-transfusion type and enterically-transmitted type, there was no reliable report about identification of cusative virus particles. Our research group sucessfully demonstrated virus particles of both non-A, non-B hepatitis for those 2 years. First, we inoculated fecal materials taken from patients with sporadic non-A, non-B hepatitis in Rangoon, Burma to the cynomolgus monkeys and we recovered virus particles from the bile of the infected animales. This virus was also successfully transmitted to the second and third generation of the animals. Concerning post-transfusion non-A, non-B hepatitis, we demonstrated virus particles in the sera of the infected chimpanzees after gradient centrifugation. Virus is 36 to 64nm in diameter and molphologicaly it resembles to togavirus. We are now trying molecular cloning of both viruses.