RESEARCH FOR THE PATHOMECHANISM, EPIDEMILOGY AND TREATMENTS FOR HAM AND HTLV-I RELATED DISORDERS.

火腿和 HTLV-I 相关疾病的发病机制、流行病学和治疗研究。

• 批准号: 03454219
• 负责人: OSAME Mitsuhiro
• 金额: $ 3.97万
• 依托单位: KAGOSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454219/
• 关键词: HAM; TSP; HTLV-I; Retrovirus; HTLV-I associated myelopathy; HTLV-I associated mylopathy; 成人T細胞白血病ウイルス; HTLVーI; HTLVーI脊髄症; 脊髄症; HTLVーI関連症候群; シェグレン症候群; HTLVーI筋炎

This research provided several important results during these two years of investigation. In Kasari-town, which is a remote island in Kagoshima, we examined 384 inhabitants. Among them, 36(9.4%) had anti-HTLV-I antibodies in the serum. A longitudinal study of carriers will be done in the coming ten years. Lymphocyte separation was performed from 800 patients and family members who were admitted at Kagoshima University hospital. All of these samples were stored in liquid nitrogen.The clinical features and the laboratory data of 208 patients with HAM were entered in the computer for analysis. The results provided several important information regarding HAM. For instance, HAM may not sometimes have anti-HTLV-I antibodies in cerebrospinal fluid. The associated diseases in patients with HAM were also analyzed and their prevalence were calculated. The pathomechanisms of HTLV-I associated arthropathy, alveolitis, Shjogren syndrome, myositis. IgA nephropathy and pseudohypoparathyroidism were investigated and several important findings could be obtained. Five autopsied cases HAM were studied for neuropathological analysis. The specific importance of CD8lymphocytes was observed. Cytotoxic CD8 cells for the pX region were also found in the blood of patients. More than ten different therapeutic regimens were tried in HAM with very encouraging results.

这项研究在这两年的调查中提供了几项重要成果。在鹿儿岛的一个偏远岛屿葛萨里镇，我们调查了384名居民。其中36例（9.4%）血清中有抗HTLV-Ⅰ抗体。在未来十年内，将对运营商进行纵向研究。从鹿儿岛大学医院收治的800名患者及其家属中进行淋巴细胞分离。将208例HAM患者的临床资料和实验室检查资料输入计算机进行分析。这些结果提供了一些关于HAM的重要信息。例如，HAM在脑脊液中有时可能没有抗HTLV-I抗体。分析HAM患者的相关疾病，并计算其患病率。HTLV-I相关关节病、肺泡炎、舍格伦综合征、肌炎的病理机制。伊加肾病和假性甲状旁腺功能减退症进行了调查，可以得到几个重要的结果。对5例HAM尸检进行神经病理学分析。观察到CD 8淋巴细胞的特殊重要性。在患者血液中也发现了pX区域的细胞毒性CD 8细胞。在HAM中尝试了十多种不同的治疗方案，取得了非常令人鼓舞的结果。

项目成果

Takahashi K, Takezaki T, Oki T, et al: "Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I." Int. J. Cancer. 49. 673-677 (1991)

Takahashi K、Takezaki T、Oki T 等人：“母源抗体对 I 型人类 T 淋巴细胞病毒母婴传播的抑制作用。”

Izumo S.,Ijichi T.,Higuchi I.et al.: "Neuropathology of HTLV-I-associated myelopathy. ーーA report of two autopsy casesーー" Acta Paediatrica Japonica. 34. 358-364 (1992)

Izumo S.、Ijichi T.、Higuchi I. 等人：“HTLV-I 相关脊髓病的神经病理学。-两个尸检病例的报告-”Acta Paediatrica Japonica 34. 358-364 (1992)。

Higuchi I.,Nerenberg M,Yoshimine K.,et al.: "Failure to detect HTLV-1 by in situ hybridization in the biopsied muscles of viral carriers with polymyositis." Muscle & Nerve. 15. 43-47 (1992)

Higuchi I.、Nerenberg M、Yoshimine K. 等人：“通过原位杂交未能在患有多发性肌炎的病毒携带者的活检肌肉中检测到 HTLV-1。”

Ijichi T.,Higuchi I.,Fukunaga H.et al.: "Lymphocyte subsets in muscle biopsied of humn T-lymphotropic virus type I carriers with polymyositis." Int.Med.31. 973-977 (1992)

Ijichi T.、Higuchi I.、Fukunaga H.等人：“患有多发性肌炎的人类 T 淋巴细胞病毒 I 型携带者肌肉活检中的淋巴细胞亚群。”

Sato K, Maruyama I, Maruyama Y, et al: "Arthritis in patients infected with human T lymphotropicvirus type I." Arthritis & Rheumatism. 34. 714-721 (1991)

Sato K、Maruyama I、Maruyama Y 等人：“感染人类 T 淋巴细胞病毒 I 型的患者出现关节炎。”