Research of Clinical Features and Pathomechanism of HAM

HAM的临床特点及发病机制研究

• 批准号: 62480208
• 负责人: OSAME Mitsuhiro
• 金额: $ 4.22万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480208/
• 关键词: HTLV-I; HAM; TSP; Treatment; Blood Transfusion; Epidemiology; Clincal; HTLV-I Associated Myelopathy; レトロウィルス; ミエロパチー; HTLVーI; 痙性脊髄麻痺; スローウィルス; ミオパチー; HTLVーIーassociated

We could establish the clinical entity of HTLV-I-associated nmyelopathy(HAM). The nationwide survay of HAM was performed and 710 patients of HAM were found to exist throughout Japan. More than 60% of them were living in Kyushu. About 26% of the patients had the previous history of blood transfusion. Clinical features were analyzed. Immunological studies were also done and activated T lymphocytes were found to be increased both in serum and CSF. Electroencephalographic abnormalities were also found in HAM. Three patients were autopsied and detailed neuropathological analysis were done. The main lesions existed at the thorathic level of the spinal cord and were consisted of inflammatory mononuclear cell infiltration around vessels and gliosis. Immunosupressive treatment were found to be effective for HAM.

我们可以建立HTLV-I相关性脊髓病（HAM）的临床实体。在日本全国范围内进行了HAM的调查，发现710例HAM患者。超过60%的人住在九州。约26%的患者有输血史。分析其临床特点。免疫学检查发现血清和脑脊液中活化T淋巴细胞均增加。HAM也有脑电图异常。3例患者进行了尸检和详细的神经病理学分析。主要病变位于脊髓胸段，由血管周围炎性单核细胞浸润和胶质细胞增生组成。免疫抑制治疗对HAM有效。

项目成果

Gustavo C.Roman;Mitsuhiro Osame: Lancet. 1. 651 (1988)

古斯塔沃·C·罗曼；大雨光宏：《柳叶刀》。

Shuji Izumo,et al: Neurology. 38. 242 (1988)

Shuji Izumo 等人：神经病学。

Osame M. Matsumoto M. Usuku K, et al: "Chronic Progressive myelopathy associated with elevated antibodies to HTLV-I and Adult T-cell Leukemia like cells." Annals of Neurology 21 117-122, 1987.

Osame M. Matsumoto M. Usuku K 等人：“慢性进行性脊髓病与 HTLV-I 和成人 T 细胞白血病样细胞抗体升高有关。”

Osame M, Igata A, Matsumoto M, et al: "HTLV-I-associated myelopathy(HAM), treatment trials, retrospective survey and clinical and laboratory findings." Hematology Reviews 3 271-284, 1990.

Osame M、Igata A、Matsumoto M 等人：“HTLV-I 相关脊髓病 (HAM)、治疗试验、回顾性调查以及临床和实验室结果。”

M.Yoshica,M.Osame,H.Kawai,et al: "Increased replication of HTLV-I in HTLV-I-associated myelopathy." Ann.Neurol. 26. 331-335 (1989)

M.Yoshica、M.Osame、H.Kawai 等人：“HTLV-I 相关脊髓病中 HTLV-I 的复制增加。”