Epidemiology and pathology of human retrovirus infection

人类逆转录病毒感染的流行病学和病理学

• 批准号: 06042013
• 负责人: OSAME Mitsuhiro
• 金额: $ 3.26万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042013/
• 关键词: Adult T-cell Leukemia; HAM; HTLV-1

The blood or sera from ethnic minority were collected in Kamtchakka, Uzbekistan (former USSR) , Unnan (south China) , Malaysia, Thailand, Singapol and south India to see prevalence of human retroviruses especially HTLV-1 and phylogenetic relation of these viruses isolated there. These studies will provide us the informations on origin and evolution of these viruses as well as movement of human beings in the past. The collected samples and the results so far obtained were followed.1. KamtchakkaIn total 622 blood samples were collected from three minority villages (Esso, Tighil and Sedanka) consisting seven minority groups such as Evenki, Koriak, Italman, Chucka Tokucha, Lamut and Alute. As a result, no serologically typical positive cases were found, but there were several suspected cases. At present, we are trying to isolate and to detect the genomes of variant viruses from these samples.2. UzbekistanThere are jewish population who moved from Iran and has been isolated from Moslem worl … More d in Buchara and Samarkand. We collected totally 279 blood samples from them including leukemia and neurologically disordered patients. Serologically they are all negative but we are trying to detect virus genomes from suspected cases.3. Unnan (south China)In total 150 serum samples were collected from minority groups consisting of I,Tai, Risu, Nashi and Myao. They were all negative for virus antibody. Six rhesus monkeys in Kunming primate facilities having HTLV-1 antibody was found and we are now isolating the virus from them.4. Thailand, Malaysia, Singapol and South IndiaSeropositive one was found from a lymphoma patient in south Thailand. In Malaysia 2,000 serum samples were screened and resulted in all seronegative. In addition, DNA extraction from seropositive Chinese is now going. In India, a new seropositive case was found in Andrapradesh State. Nine percent of seropositive cases were found in 1,000 samples collected from Papua Newguinea, which has been kept in Singapol University. Less

少数族裔的血液或血清是在乌兹别克斯坦的卡姆查卡（Kamtchakka）收集的，前苏联（前苏联），中国南部（南部），马来西亚，泰国，泰国，新加坡和印度南部，以观察到人类逆转录病毒的流行，尤其是HTLV-1，尤其是HTLV-1和这些病毒的系统发育关系。这些研究将为我们提供有关这些病毒的起源和进化以及过去人类运动的信息。遵循收集的样品和到目前为止获得的结果。1。从三个少数村庄（Esso，Tighil和Sedanka）收集了Kamtchakkain，总共收集了622个血样，包括七个少数群体，例如Evenki，Koriak，Italman，Chucka Tokucha，Lamut和Alute。结果，未发现血清学典型的阳性病例，但有几例可疑病例。目前，我们正在尝试分离并检测这些样品的变异病毒的基因组。2。乌兹别克斯坦人是从伊朗移居的犹太人，并已与穆斯林·沃尔（Moslem Worl）隔离……在布卡拉（Buchara）和撒马尔罕（Samarkand）中更多的D。我们从其中完全收集了279种血液样本，包括白血病和神经系统疾病的患者。从血清学上讲，它们都是阴性的，但我们试图从可疑病例中检测病毒基因组3。来自I，Tai，Risu，Nashi和Myao的少数群体收集了总共150种血清样品。它们对病毒抗体都是阴性的。发现了具有HTLV-1抗体的Kunming灵长类动物设施中的六只恒河猴，我们现在正在将病毒与之隔离。4。泰国，马来西亚，新加坡和南部的印度阳性阳性，是从泰国南部的一名淋巴瘤患者中发现的。在马来西亚，筛选了2,000种血清样品，并导致所有血清剂。此外，现在正在从血清阳性汉中提取DNA。在印度，在安德拉普拉德州发现了一个新的血清阳性病例。在从新加坡大学中保存的1,000个样本中发现了9％的血清反应病例。较少的

项目成果

Ono, A., et al.: "Subtype analysis of the HTLV-1 in patients with HTLV-1 uveities, a new disease entity associated with HTLV-1" Jpn.J.Cancer Res.32. 767-770 (1994)

Ono, A. 等人：“HTLV-1 葡萄膜患者的 HTLV-1 亚型分析，一种与 HTLV-1 相关的新疾病实体”Jpn.J.Cancer Res.32。

Ono,A.,et al.: "Subtype analysis of the HTLV-1 in patients with HTLV-1 uveities,a new disease entity associated with HTLV-1" Jpn.J.Cancer Res.85. 767-770 (1994)

Ono,A.,et al.：“HTLV-1 葡萄膜患者的 HTLV-1 亚型分析，一种与 HTLV-1 相关的新疾病实体”Jpn.J.Cancer Res.85。

速水正憲: "サルから学ぶエイズ〜HIVの起源と病原性" 科学. 62. 452-461 (1994)

Masanori Hayami：“从猴子身上了解艾滋病——艾滋病毒的起源和发病机制”《科学》62. 452-461 (1994)。

Urabe, T., et al.: "Differentiation between human Immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates by nonradioisotopic reverse trancriptase-typing assay" J.Clinic Microbiol.32. 1870-1875 (1994)

Urabe, T. 等人：“通过非放射性同位素逆转录酶分型测定区分人类免疫缺陷病毒 1 型 (HIV-1) 和 HIV-2 分离株”J.Clinic Microbiol.32。

Yamashita.M., et al.: "HTLV-1 from Iranian Mashhadi in Israel is phylogenetically related to that of Japan, India and South America rather than to those of Africa and Melanesia" Virus Gene. (in press). (1995)

Yamashita.M.等人：“来自以色列伊朗马什哈迪的HTLV-1在系统发育上与日本、印度和南美洲的HTLV-1相关，而不是与非洲和美拉尼西亚的HTLV-1相关”病毒基因。