Epidemiology and pathology of human retrovirus infection

人类逆转录病毒感染的流行病学和病理学

• 批准号: 06042013
• 负责人: OSAME Mitsuhiro
• 金额: $ 3.26万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042013/
• 关键词: Adult T-cell Leukemia; HAM; HTLV-1

The blood or sera from ethnic minority were collected in Kamtchakka, Uzbekistan (former USSR) , Unnan (south China) , Malaysia, Thailand, Singapol and south India to see prevalence of human retroviruses especially HTLV-1 and phylogenetic relation of these viruses isolated there. These studies will provide us the informations on origin and evolution of these viruses as well as movement of human beings in the past. The collected samples and the results so far obtained were followed.1. KamtchakkaIn total 622 blood samples were collected from three minority villages (Esso, Tighil and Sedanka) consisting seven minority groups such as Evenki, Koriak, Italman, Chucka Tokucha, Lamut and Alute. As a result, no serologically typical positive cases were found, but there were several suspected cases. At present, we are trying to isolate and to detect the genomes of variant viruses from these samples.2. UzbekistanThere are jewish population who moved from Iran and has been isolated from Moslem worl … More d in Buchara and Samarkand. We collected totally 279 blood samples from them including leukemia and neurologically disordered patients. Serologically they are all negative but we are trying to detect virus genomes from suspected cases.3. Unnan (south China)In total 150 serum samples were collected from minority groups consisting of I,Tai, Risu, Nashi and Myao. They were all negative for virus antibody. Six rhesus monkeys in Kunming primate facilities having HTLV-1 antibody was found and we are now isolating the virus from them.4. Thailand, Malaysia, Singapol and South IndiaSeropositive one was found from a lymphoma patient in south Thailand. In Malaysia 2,000 serum samples were screened and resulted in all seronegative. In addition, DNA extraction from seropositive Chinese is now going. In India, a new seropositive case was found in Andrapradesh State. Nine percent of seropositive cases were found in 1,000 samples collected from Papua Newguinea, which has been kept in Singapol University. Less

在Kamtchakka、乌兹别克斯坦（前苏联）、Unnan（中国南部）、马来西亚、泰国、新加坡和印度南部采集少数民族的血液或血清，以了解人类逆转录病毒特别是HTLV-1的流行情况以及这些病毒在那里分离的系统发育关系。这些研究将为我们提供这些病毒的起源和进化以及过去人类活动的信息。收集的样本和迄今为止获得的结果如下。Kamtchakka从三个少数民族村庄（Esso、Kriil和Sedanka）共采集了622份血样，这些村庄包括七个少数民族群体，如Evenki、Koriak、Italman、Chucka Tokucha、Lamut和Alkarte。结果，未发现血清学典型阳性病例，但有几例疑似病例。目前，我们正试图从这些样本中分离和检测变异病毒的基因组。乌兹别克斯坦有犹太人谁从伊朗迁移，并已从穆斯林世界隔离 ...更多信息 d在Buchara和撒马尔罕。共采集血液标本279份，包括白血病和神经系统疾病患者。血清学检测结果均为阴性，但我们正试图从疑似病例中检测病毒基因组。云南（中国南方）共收集了150份血清样本，包括I族、Tai族、Risu族、Nashi族和Myao族。病毒抗体均为阴性。在昆明灵长类动物饲养所的6只恒河猴中发现了HTLV-1抗体，目前正在进行病毒分离.泰国、马来西亚、新加坡和印度南部发现一例来自泰国南部淋巴瘤患者的血清阳性。在马来西亚，对2 000份血清样本进行了筛查，结果全部呈血清阴性。此外，从血清阳性的中国人中提取DNA的工作正在进行中。在印度，在安德拉普拉德什州发现了一例新的血清反应阳性病例。从巴布亚新几内亚收集的1,000个样本中发现了9%的血清阳性病例，这些样本一直保存在新加坡大学。少

项目成果

Ono, A., et al.: "Subtype analysis of the HTLV-1 in patients with HTLV-1 uveities, a new disease entity associated with HTLV-1" Jpn.J.Cancer Res.32. 767-770 (1994)

Ono, A. 等人：“HTLV-1 葡萄膜患者的 HTLV-1 亚型分析，一种与 HTLV-1 相关的新疾病实体”Jpn.J.Cancer Res.32。

速水正憲: "サルから学ぶエイズ〜HIVの起源と病原性" 科学. 62. 452-461 (1994)

Masanori Hayami：“从猴子身上了解艾滋病——艾滋病毒的起源和发病机制”《科学》62. 452-461 (1994)。

Ono,A.,et al.: "Subtype analysis of the HTLV-1 in patients with HTLV-1 uveities,a new disease entity associated with HTLV-1" Jpn.J.Cancer Res.85. 767-770 (1994)

Ono,A.,et al.：“HTLV-1 葡萄膜患者的 HTLV-1 亚型分析，一种与 HTLV-1 相关的新疾病实体”Jpn.J.Cancer Res.85。

Urabe, T., et al.: "Differentiation between human Immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates by nonradioisotopic reverse trancriptase-typing assay" J.Clinic Microbiol.32. 1870-1875 (1994)

Urabe, T. 等人：“通过非放射性同位素逆转录酶分型测定区分人类免疫缺陷病毒 1 型 (HIV-1) 和 HIV-2 分离株”J.Clinic Microbiol.32。

Ishida,T.,et al.: "Human T-lymphotropic retrovirus type-1 (HTLV-1)and its distribution in Asian populations." Southeatern Journal of Tropical. (in press). (1995)

Ishida,T.,et al.：“人类 T 淋巴细胞逆转录病毒 1 型 (HTLV-1) 及其在亚洲人群中的分布。”