Epidemiology and pathology of human retro virus infection.

人类逆转录病毒感染的流行病学和病理学。

• 批准号: 04042017
• 负责人: OSAME Mitsuhiro
• 金额: $ 7.3万
• 依托单位: Kagoshima Universitiy
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04042017/
• 关键词: ATL; HTLV-I; HTLV-II; HAM; TSP; STLV; HIV-I; HIV-II; SIV; HIV; STLV-I

1. HTLV-I isolated from Gabon made one cluster with HTLV-I from Zaire and STLV-I from chimpanzee, suggesting interspecies transmission between human and chimpanzee in Central Africa.2. SIV from white crowned mangabey in Kenya belonged to SIVagm group of African green monkey, suggesting interspecies transmission between them. STLV-I from African green monkey is subspecies-specific but closely related to inhabiting places.3. HTLV-I and HTLV-II in Ghana are highly heterogeneous. There exist HIV-I variants which had not been reported. HIV-II variants distinct from known HTV-II group was a present. This new HIV-II subgroup was designated as HIV-IIb. HTLV-I from Ghana belonged to HTLV-I c type together with Caribian HTLV-I. HTLV-II from Ghana belonged to HTLV-II a type.4. In India, a case of ATL and 3 cases of HAM/TSP were found. Neucleotides sequences of 2 HTLV-I proviruses isolated from HAm/TSP cases showed 98-99% homologies with prototypes HTLV-I.5.HTLV-I carriers were found in southern Thailand. Among Orang Asli, indigenous populations in Malay Penicula, 15 of 300 sera showed positive reactions in PA test.6. In Indonesia, there are HTLV-I carriers and HAM/TSP patients. Indonesian apes such as orangutan and monkeys are carriers of STLV-I.7. It is suggested that some minority groups in Unnann District, China keep HTLV-I.8. A high frequency of HTLV-I carriers and HAM patients were seen in Masahhdi Jews who moved from Iran. Their HTLV-I belonged to HTLV-I A type which is also seen in Japan and India, and is rather homorogous.9.In Australia, HAM/TSP and ATL cases were found in indigenous populations. One HAM/TSP case was also found in Korea.

1. 1 .从加蓬分离的htlv - 1与扎伊尔分离的htlv - 1和黑猩猩分离的stlv - 1形成一个聚类，提示中非人类和黑猩猩之间存在种间传播。肯尼亚白冠白眉猴的SIV属于非洲绿猴SIVagm群，表明它们之间存在种间传播。来自非洲绿猴的STLV-I是亚种特异性的，但与栖息地密切相关。HTLV-I和HTLV-II在加纳是高度异质的。存在未被报道的hiv - 1变异。与已知HTV-II组不同的HIV-II变体也存在。这个新的HIV-II亚群被命名为HIV-IIb。来自加纳的HTLV-I与来自加勒比的HTLV-I一起属于HTLV-I c型。来自加纳的HTLV-II属于HTLV-II a型4。在印度，发现1例ATL和3例HAM/TSP。从HAm/TSP病例中分离的2个htlv - 1前病毒的核苷酸序列与原型htlv - 1 - 5的同源性为98-99%。泰国南部发现了htlv - 1携带者。马来青霉在原住民原住民原住民原住民中，300份血清中有15份呈阳性反应。在印度尼西亚，有HTLV-I携带者和HAM/TSP患者。印度尼西亚的猩猩和猴子等猿类是stlv - i - 7的携带者。建议中国云南区部分少数民族保留HTLV-I.8。HTLV-I携带者和HAM患者在从伊朗移居的Masahhdi犹太人中出现的频率很高。他们的HTLV-I属于HTLV-I A型，这种类型在日本和印度也可以看到，而且相当同源。在澳大利亚，在土著人群中发现了HAM/TSP和ATL病例。韩国也发现1例HAM/TSP病例。

项目成果

Sonoda S.: "Ethnically-defined immunogenetic factors involved in the pathogenesis of HTLV-I-asociated diseases." Biotest Bulletin. 5. 79-88 (1993)

Sonoda S.：“种族定义的免疫遗传因素参与 HTLV-I 相关疾病的发病机制。”

Hashimoto K.,Lalkaka J.,Fujisawa J.et al.: "Limited sequence divergence of HTLV-I of Indian HAM/TSP patients from a prototype Japanese" AIDS Research and Human retrovirus. 9. 495-498 (1993)

Hashimoto K.、Lalkaka J.、Fujisawa J.等人：“印度 HAM/TSP 患者的 HTLV-I 与日本原型”艾滋病研究和人类逆转录病毒的有限序列差异。

L.Cartier: "Southernmost Carriers of HTLV-I/II in the world." Jpn.J.Cancer Res.84. 1-3 (1993)"Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy."

L.Cartier：“世界最南端的 HTLV-I/II 航母。”

Osame M.,Kumamoto I.,Izumo S,et al.: "HTLV-I-associated myelopathy(HAM):Epidemiology,clinical features,and pathomechanism.Gann Monograph on Cancer Research." Jpn.Sci.Soci.Press., 261 (1992)

Osame M.、Kumamoto I.、Izumo S 等人：“HTLV-I 相关脊髓病 (HAM)：流行病学、临床特征和病理机制。江恩癌症研究专着。”