Study of atomic Ne penning laser for photodynamic therapy of cancer

原子氖潘宁激光光动力治疗癌症的研究

• 批准号: 04452205
• 负责人: OBARA Minoru
• 金额: $ 3.97万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04452205/
• 关键词: penning laser; photodynamic therapy; HpD; atomic laser; cancer treatment; noen laser; rare-gas laser; ペニング反応

The atomic neon penning laser for photodynamic therapy of cancer is studied experimentally and theoretically. As a result, the following results are obtained :(1)Using a neon penning laser code developed by us, the operational conditions for achieving high energy output and high efficiency are made clear.(2)It is found that the optimun gas mixture is Ne/H_2=16/40 Torr and the optimum pumping rate is 0.5 MW/cm^3. At this parameter the output power density of 4.4 W/cm^3 is obtained at an efficiency of 8.5x10^<-6>.(3)At higher pump rates than 0.5 MW/cm^3, deactivation of the upper laser level by discharge electron becomes larger, resulting in the decrease of the efficiency.(4)Achievement of the stable discharge leads to the klowatt-class neon laser.(5)As a penning partner of the neon laser, H_2 is better than D_2.(6)By delivering the neon laser pulse through the quarts fiber, HpD is efficiently pumped.

对用于癌症光动力治疗的原子霓虹激光进行了实验和理论研究。结果表明：(1)利用自行开发的霓虹灯激光程序，明确了获得高能量输出和高效率的工作条件.(2)得到了最佳混合气体为Ne/H_2=16/40Torr，最佳泵浦速率为0.5 mW/cm~3.在此参数下，获得了4.4W/cm~3的输出功率密度，效率为8.5×10~(-6)×10~(-6)×10~(-3)；(3)在高于0.5 mW/cm~3的泵浦速率下，放电电子对上激光能级的失活较大，导致效率降低.(4)实现稳定的放电导致Klowatt级Ne激光器.(5)作为Ne激光器的辅助材料，H_2优于D_2.(6)通过石英光纤传输Ne激光脉冲，可以有效地泵浦HPD.

项目成果

C.H.Yang,K.Itoh,H.Tomita,M.Obara: "Scaling law of the atomic neon penning laser for photodynamic therapy of human cancer" J.Applied Physics. (発表予定).

C.H.Yang、K.Itoh、H.Tomita、M.Obara：“用于人类癌症光动力治疗的原子氖潘宁激光的缩放定律”J.应用物理学（待提交）。

Chuen‐Huei Yang: "Output characteristics of high‐pressure 585.3nm atomic neon laser pumped by transverse discharge" SPIE Vol.1871:Intense Laser Beams and Applications. 1871. (1993)

Chuen-Huei Yang：“横向放电泵浦的高压 585.3nm 原子氖激光器的输出特性”SPIE Vol.1871：强激光束和应用 1871。（1993 年）

C.H.Yang, K.Itoh, H.Tomita, M.Obara: "Scaling law of the atomic neon penning laser for photodynamic therapy of human cancer" J.Appl.Phys. (to be published).

C.H.Yang、K.Itoh、H.Tomita、M.Obara：“用于人类癌症光动力治疗的原子氖潘宁激光的缩放定律”J.Appl.Phys。

Chuen-Huei Yang: "Output characteristics of high-pressure 585.3nm atomic neon laser pumped by transverse discharge" SPIE:Intense Laser Beams and Applications. 1871. 57-61 (1993)

Chuen-Huei Yang：“横向放电泵浦的高压585.3nm原子氖激光器的输出特性”SPIE：强激光束和应用。

C.H.Yang,K.Itoh,T.Araki,F.Kannari,M.Obara: "Output characteristics of high-pressure 585.3nm atomic neon laser pumped by transverse discharge" SPIE:Intense Laser Beams and Application. 1871. 57-61 (1993)

C.H.Yang，K.Itoh，T.Araki，F.Kannari，M.Obara：“横向放电泵浦的高压585.3nm原子氖激光器的输出特性”SPIE：强激光束及其应用。