Air pollution with carcinogenic heterocyclic amines and their sources in the environment.

致癌杂环胺的空气污染及其环境来源。

• 批准号: 04454215
• 负责人: MANABE Shigeo
• 金额: $ 4.22万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454215/
• 关键词: carcinogen; Heterocyclic amine; Airborne particles; Air pollution; Diesel-exhaust; Cigarette smoke

In the last 15 years a series of mutagenic heterocyclic amines have been found in cooked meat an fish. A number of these compounds have been shown to be multisite rodent carcinogens. Among them, PhIP (2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine), A alpha C(2-amino-9H-pyrido[2,3-b]indole) and MeA alpha C (2-amino-3-methyl-9H-pyrido[2,3-b]indole) are considered to be important mutagenic-carcinogenic heterocyclic amines because of their high content in various cooked foods. This project is focused on the distribution and formation mechanism of these carcinogens in the environment such as air. We have clearly demonstrated the followings :(1)A alpha C and MeA alpha C are present measured in airborne particles, rain water soil and cigarette-smoke-polluted indoor air.(2)PhIP has been measured in airborne particles, diesel-exhaust particles, and incineration ash from garbage-burning plants. PhIP was found in all kinds of samples.(3)These findings described above suggest that carcinogenic heterocyclic amines are formed through combustion of various materials such as food, grass and petroleum.(4)Either sugar or aldehyde is an important reactant i PhIP formation.(5)Pentose in nucleic acids may participate in PhIP forming reactions.

在过去的15年里，在熟肉和鱼中发现了一系列致突变的杂环胺。这些化合物中的一些已被证明是多位点啮齿动物致癌物。其中，PhIP（2-氨基-1-甲基-6-苯基-咪唑并[4，5-B]吡啶）、A alpha C（2-氨基-9H-吡啶并[2，3-B]吲哚）和MeA alpha C（2-氨基-3-甲基-9H-吡啶并[2，3-B]吲哚）因在各种熟食中含量较高，被认为是重要的致突变-致癌杂环胺。本项目的重点是这些致癌物在空气等环境中的分布和形成机制。结果表明：（1）大气颗粒物、雨水、土壤和受煤烟污染的室内空气中都存在A α C和MeA α C。（2）PhIP已在空气中的颗粒物、柴油机废气颗粒物和垃圾焚烧厂的焚烧灰中测量。各种样品中均检出PhIP。（3）上述研究结果表明，致癌的杂环胺是通过燃烧各种物质如食物、草和石油而形成的。（4）糖或醛是PhIP形成的重要反应物。（5）核酸中的戊糖可能参与PhIP形成反应。

项目成果

Manabe,S.et al: "A fluorescent carcinogen(PhIP) in human lens" Experimental Eye Research. 57. 319-324 (1993)

Manabe,S.et al：“人晶状体中的荧光致癌物（PhIP）”实验眼研究。

Manabe,S.et al: "Formation of PhIP in a mixture of creatinine,phenylalanine and sugars or aldehyde by aqueous heating" Carcinogenesis. 13. 827-830 (1992)

Manabe,S.et al：“通过水加热在肌酸酐、苯丙氨酸和糖或醛的混合物中形成 PhIP”致癌作用。

Manabe,S.et al: "Detection of the carcinogen(PhIP)in beer and wine" Carcinogenesis. 14. 899-901 (1993)

Manabe,S.et al：“啤酒和葡萄酒中致癌物（PhIP）的检测”致癌作用。

Manabe,S.et al: "Occurrence of carcinogenic amino-α-carbolines in some environmental samples" Environmental Pollution. 75. 301-305 (1992)

Manabe, S. 等人：“某些环境样品中存在致癌性氨基-α-咔啉”，《环境污染》75. 301-305 (1992)。

Manabe,S.et al: "Nucleic acids induce the formation of a carcinogen(PhIP) in a model system" Carcinogenesis. 14. 903-906 (1993)

Manabe,S.et al：“核酸在模型系统中诱导致癌物 (PhIP) 的形成”致癌作用。