Identifying the niche of perivascular immune cells

识别血管周围免疫细胞的生态位

• 批准号: 431347925
• 负责人: Professor Dr. Tim Lämmermann, Ph.D.
• 金额: --
• 依托单位: Centre dImmunologie de Marseille-Luminy (CIML)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/431347925?language=en
• 关键词: Identifying; niche; perivascular; immune; cells

Immune cells distribute throughout all tissues to protect our body from pathogens. It has long been acknowledged that macrophages and mast cells decorate the outer surfaces of cutaneous blood vessels and regulate their functions. However, the molecular identity of this crosstalk is largely unknown. In particular, we are missing a detailed understanding about how different vessel types and vascular components shape the specific "niche" that regulates the identity and function of perivascular immune cells in the skin. By using in situ imaging in combination with mouse genetics, we will investigate (a) the functional role of specific blood vessel components (endothelial cells, pericytes, vascular smooth muscle cells, nerves) in regulating the homeostasis and defining the phenotype of perivascular macrophages and mast cells, and (b) the signals and molecules that control the perivascular localization of these cells. Our studies will provide important novel insight into both, the local regulation of perivascular immune cells, as well as the physiological functions they exert in the skin, findings that likely can be extrapolated to other peripheral tissues.

免疫细胞分布在所有组织中，以保护我们的身体免受病原体的侵害。巨噬细胞和肥大细胞在皮肤血管的外表面起着重要的装饰作用，并调节着血管的功能。然而，这种串扰的分子身份在很大程度上是未知的。特别是，我们缺乏对不同血管类型和血管成分如何塑造特定“生态位”的详细了解，这些特定“生态位”调节皮肤中血管周围免疫细胞的身份和功能。通过使用原位成像结合小鼠遗传学，我们将研究（a）特定血管成分（内皮细胞，周细胞，血管平滑肌细胞，神经）在调节体内平衡和定义血管周围巨噬细胞和肥大细胞表型中的功能作用，以及（B）控制这些细胞血管周围定位的信号和分子。我们的研究将为血管周围免疫细胞的局部调节以及它们在皮肤中发挥的生理功能提供重要的新见解，这些发现可能可以外推到其他外周组织。