Natural History and Counterplan of Benign Prostatic Hyperplasia

良性前列腺增生的自​​然史及对策

• 批准号: 04454399
• 负责人: SHIMAZAKI Jun
• 金额: $ 4.16万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454399/
• 关键词: Benign Prostatic Hyperplasia; Dysuria; Urodynamics; Latent carcinoma of the prostate; Rat prostate tumor; Flutamide; PSA; Antiandrogen; R3327; アンドロゲンレセプター; 偶発前立腺癌; 前立腺; 尿流量率

(1) Natural history and treatment.Prostatic sizes of health care cases varied widely along with increasing age, but could be divided into two groups ; increasing or no change. According to serial determinations, annual growth rate of the prostate in the increasing group was calculated as 1.65<plus-minus>1.13 g and 0.85<plus-minus>0.44 g in men<65 years old and<greater than or similar>65 years old, respectively. Distribution of prostatic sizes as a function of age in health care cases was similar to that in operated patients at the hospitals except extremely large prostate in small number of operated cases. Thus prostatic sizes are not correlated well to urinary symptoms or surgical indication. Uroflow rate decreased along with increasing age in no change group, thus aging is a risk factor in disturbanceTreatment of benign prostatic hyperplasia was divided mainly into medication or operation. Indication of method was chosen according to grade of symptom and objective signs. Patients wit … More h high grade of symptom and objective signs in medication group showed tendency to perform operation thereafter, therefore, medication revealed limitation for improvement of disease.(2) Urodynamics.At maximum flow, bladder neck diameter more than 7 mm did not lose hydraulic energy at bladder neck and proximal urethra, but that less than 7 mm lost the energy significantly. Thus opening of bladder neck more than 7 mm required for smooth micturition.(3) Effect of early exposure of antiandrogen on subsequent growth of rat prostatic tumor (Dunning R-3327).Recently various drugs including antiandrogen have been used for treatment of benign prostatic hyperplasia, influence of these drugs on concomittant latent cancer has arisen as important problem. To examine on this problem, rat prostatic tumor after transplantation was assumed as latent cancer and influence of flutamide injected during short period on subsequent growth was observed. Flutamide delaydan appearance of the tumor nodule and retarded the growth rate in proportion as treatment began earlier. Flutamide also reduced final tumor volume. However, androgen-sensitive properties in the tumor were not alteredby flutamide. Thus, antiandrogen treatment to benign prostatic hyperplasia may not affect significantly on properties of concomittant latent cancer in the prostate. Less

(1)自然史及治疗。保健病例的前列腺大小随年龄的增长变化很大，但可分为两组；增加或不变。根据连续测定，在<65岁和<大于或类似于65岁的男性中，增加组前列腺年增长率分别为1.65<正负>1.13 g和0.85<正负>0.44 g。保健病例中前列腺大小随年龄的分布与医院手术患者相似，但少数手术病例中前列腺异常大。因此前列腺大小与泌尿系统症状或手术指征没有很好的相关性。无变化组尿流率随年龄的增加而下降，表明年龄是干扰的危险因素。良性前列腺增生的治疗主要分为药物治疗和手术治疗。根据症状分级和客观体征选择方法适应证。用药组患者症状及客观体征分级较高，术后倾向于行手术治疗，用药对病情改善的作用有限。(2)尿动态。最大流量时，膀胱颈直径大于7 mm的膀胱颈及尿道近端水能损失不明显，小于7 mm的膀胱颈及尿道近端水能损失明显。因此，膀胱颈部开口大于7毫米，需要顺利排尿。(3)早期暴露抗雄激素对大鼠前列腺肿瘤后续生长的影响（Dunning R-3327）。近年来，包括抗雄激素在内的各种药物被用于治疗良性前列腺增生，这些药物对并发潜伏癌的影响已成为一个重要的问题。为了探讨这一问题，我们假设移植后的大鼠前列腺肿瘤为潜伏癌，观察短时间内注射氟他胺对后续生长的影响。氟他胺延缓了肿瘤结节的出现，并随着治疗开始的早成比例地延缓了肿瘤的生长速度。氟他胺也能减少最终肿瘤体积。然而，氟他胺并未改变肿瘤中的雄激素敏感性。因此，抗雄激素治疗良性前列腺增生可能不会显著影响前列腺潜伏癌的特性。少

项目成果

Kitagawa,No,Shimazaki,J.et al.: "Natural course of human benign prostatic hyperplasia with relation to urinary disturbance." Prostate. 24. 279-284 (1994)

Kitakawa，No，Shimazaki，J.et al.：“人类良性前列腺增生的自​​然过程与排尿障碍的关系。”

村上信乃,島崎淳,ほか: "Stage Al前立腺偶発癌に対する再TURの意義" 日本泌尿器科学会誌. 85. 1213-1217 (1994)

Shinno Murakami、Jun Shimazaki 等人：“重复 TUR 对于 Al 期偶发性前列腺癌的意义”，日本泌尿外科协会杂志 85. 1213-1217 (1994)。

溝上 敦 ほか: "ヒトアンドロゲンレセプター・ポリクローナル抗体の作製および前立腺組織におけるヒトアンドロゲンレセプター" 日本沁尿器科学会誌. 83. 1801-1807 (1992)

Atsushi Mizokami 等：“人雄激素受体多克隆抗体和前列腺组织中的人雄激素受体的制备”日本泌尿学会杂志 83. 1801-1807 (1992)。

Yamanishi,T.,Shimazaki,J.et al.: "Effects of beta2-stimulants on contractility and fatigue of canine urethral sphincter." J.Urol.151. 1066-1069 (1994)

Yamanishi,T.,Shimazaki,J.et al.：“β2 兴奋剂对犬尿道括约肌收缩性和疲劳的影响。”

北川憲一,島崎淳 ほか: "前立腺肥大症に対する薬物療法の経過と限界" 泌尿器科紀要. 40. 781-788 (1994)

Kenichi Kitakawa、Jun Shimazaki 等人：“良性前列腺增生药物治疗的过程和局限性”泌尿学通报 40. 781-788 (1994)。